Search results for " purification"
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CMOs Continue to Improve Overall Biomanufacturing Performance
That may partly be due to the current bottlenecks being experienced in purification and separation operations. And CMOs’ experience with multiple products and campaigns provide them expertise that in-…
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Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
Temperature, pH, cell density, and concentrations of nutrients and metabolites are typical CPPs during cell culture, while other CPPs are important during purification. Controlling these parameters ca…
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Webinar about a new affinity chromatography technology for recombinant proteins
Watch this webinar to learn more about this new affinity chromatography technology!
Who should watch this webinar?
• Scientists who are already working with tagged protein purification technol…
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Digitalization: The Route to Biopharma 4.0
Digital Twin of a Continuous Chromatography Process for mAb Purification: Design and Model-based Control. Biotechnol. Bioeng. 2023, 120, 748–766. DOI: 10.1002/bit.28307
11. Thakur, G.; Ghumade, …
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Chromatography innovations for the diverse antibody pipeline
For antibody variants, platform purification protocols for conventional mAb aren’t always providing sufficient outputs — some variants need new ligands, new base matrices, or new chromatography system…
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Purifying Tagged Proteins: Learn the Basics
When and why should you use it? Learn the basics in our quick guide to tagged protein purification.
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Purifying Samples for Cryo-EM Preps
Cryo-EM has opened new opportunities for determining large and complex molecules, but on the other hand, has introduced new challenges for purification of samples.
Join us to learn about:
- Ma…
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2019’s Top Bioprocessing Trends and What to Expect in 2020
Speaking of purification, new types of molecules such as bispecific antibodies (BsAbs) have also created issues in this area. Bioprocess Development Forum provided insights into “navigating the jungle…
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Modeling the Degradation of mAb Therapeutics
Buffer exchange was used to monitor the aggregation kinetics of this mAb under the conditions that are prevalent in the biopharmaceutical industry during downstream purification.
Detailed expe…
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Understanding Validation and Technical Transfer, Part I
Large-molecule drug products and attendant manufacturing processes often involve complex syntheses and purification steps that differ substantially from those employed for small-molecule pharmaceutica…