Search results for " multicolumn" in Articles / App Notes
Article
Making the Move to Continuous Chromatography
In continuous multicolumn chromatography, the large column is effectively split into a number of much smaller columns that operate in series over a larger number of cycles. While product is loaded on …
Article
Continuous Chromatography: Trends, Definitions and Approaches
As this movement is seen periodically, one could argue that the name Periodic Counter Current (PCC) is the most appropriate to describe what is really happening in a multicolumn system. However, for t…
Article
Strategies and Emerging Technologies for mAb Capture
We will discuss opportunities with the introduction of high-capacity protein A resins, how and when multicolumn chromatography is beneficial, and how emerging technologies such as rapid cycling Fibro …
Article
Scaling Up Novel Therapies
One way they do this, he says, is by “scaling out,” intensifying processes, for example by using fed-batch and perfusion on the upstream side, and multicolumn operations, whether it’s just higher cycl…
Article
Explore the Process Intensifier App
• Downstream capture (protein A step) operations: explore the possibilities of high-capacity resins, Fibro rapid cycling, and continuous multicolumn chromatography.
• Both as a connected operati…
Article
Technology Innovations Improve Process Chromatography Performance
A practical way to address this productivity increase is by utilizing a multicolumn approach. This approach has recently gained traction due to the availability of functionally closed single-use manif…
Article
Continuous Manufacturing: A Changing Processing Paradigm
Apr 01, 2015
By Randi Hernandez
BioPharm International
Volume 28, Issue 4
Although continuous manufacturing is well established for bulk chemicals, complex automation and validation …