Search results for " scale-up" in Articles / App Notes
Article
Advanced Technologies Facilitate Scale-up and Technology Transfer
FDA’s focus on the need for updates is creating both opportunities and challenges for biologics manufacturers involved in the scale-up and transfer of production technologies. Single-use and modular t…
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Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The white paper includes a brief discussion around modern vaccine processes, followed by a case study showing the scale-up of upstream and downstream processes for the production of a cell based live …
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FAQ: Scale-up and scale-down with mechanistic modeling
The model eases scale-up and scale-down between lab scale and production scale. To apply model-based scale-up and scale-down in a straightforward manner, you must know the scale-dependency of the unde…
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Factors Which Impact mAb Process Scale-Up
Fast Trak™ scientists discuss factors that can influence a successful scale-up outcome.
Article
Multidimensional Scale-Up of a Monoclonal Antibody Capture Step, Using ÄKTA™ pilot 600
In this work, a multidimensional scale-up (change of both column diameter and bed height) of a mAb capture step, using the ÄKTA pilot 600 chromatography system, is demonstrated. Column volume per…
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Considerations in depth filter scale-up
…es, what parameters to focus on during development, and how to set appropriate safety factors during scale-up.
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Article
A Look into Biologic Scale-Up Strategies
Optimizing cell-culture processes for monoclonal antibody (mAb) production is a key factor in scaling up manufacturing to commercial levels. To maximize cell-culture output, strategy is requir…
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Scale-Up Model of a mAb Process from Microbioreactor to XDR-1000
A theoretical scale-up study was performed on a mAb process based on physical characterizations done on the Xcellerex XDR platform, from micro reactors up to large production-sized reactors. All inves…
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Selected courses from cell culture and downstream process development to scale-up and manufacturing
Develop your skills and those of your teams with training courses designed for researchers, process development scientists, engineers, and manufacturing operators.
Built upon our expertise…
Article
Q&A: Oligonucleotide synthesis in process development and scale-up
Farlow
In this video, Greg Farlow, RNA/DNA synthesis product specialist at Cytiva, talks about the typical challenges with oligonucleotide synthesis in process development and key cons…