Search results for " upstream" in Articles / App Notes
Article
Accelerated flavivirus vaccine production with modern tools and solutions
This white paper gives an overview of modern tools and solutions, adding flexibility and speed to both upstream and downstream operations in flavivirus vaccine production.
Single-use production bi…
Article
Evaluating E&L Studies for Single-Use Systems
For example, a bag or a filter used for the final filtration of bulk drug substance will have a significantly higher rating compared with the components used in the upstream process steps.
Figure …
Article
Technical and Process Economical Aspects of Using Capto™ Q and ReadyToProcess™Adsorber Q in mAb Polishing
Increasing product titers in upstream cell culture processes pose challenges to downstream purification processes. For efficient operations, downstream purification needs to be able to handle high p…
Article
Advancing Single-Use Technology Through Collaboration
…ence between that and a system that uses fully single-use technology is the bioreactor, which is far upstream: there are significant purification processes in place further downstream. According to D…
Article
A Q&A with Eric Langer: CMOs Embrace New Technology
…ested in: chromatography, single-use probes and sensors, disposable chromatography, instrumentation, upstream process development services, etc. In comparison, biopharmaceutical innovators sought imp…
Article
Downstream Processing Continues to Worry CMOs
Downstream continues to fail to keep up with the recent advances in upstream yield and titers.
Reference
1. BioPlan Associates, 13th Annual Report and Survey of Biopharmaceutical Manufacturi…
Article
An Integrated Approach to Ensure the Viral Safety of Biotherapeutics
Testing product and process intermediates alone is helpful, but does not provide a complete solution to viral safety. This article proposes integrated solutions for systemic and proactive viral risk m…
Article
A Q&A on Bioprocessing Trends and Technologies at INTERPHEX 2016
Parrish Galliher, chief technology officer, upstream, Cytiva, provided an overview of the KUBio facility and FlexFactory equipment at INTERPHEX.
Complexity and scale are two stumbling blocks to the…
Article
CMOs Concerned With Cost of Single-Use Equipment
Given that CMOs expect to increase their budgets by as much as 6% for new technologies to improve upstream and downstream efficiency—with single-use equipment presumably a part of this spending—budget…
Article
Best Practices in Qualification of Single-Use Systems
SUS Process Development
Single-use systems are being used in almost all stages of biomanufacturing processes, including upstream, downstream, and fill/finish operations. Figure 1 depicts a typical…