Search results for " bioprocess" in Articles / App Notes
Article
An Integrated Approach to Ensure the Viral Safety of Biotherapeutics
Testing product and process intermediates alone is helpful, but does not provide a complete solution to viral safety. This article proposes integrated solutions for systemic and proactive viral risk m…
Article
A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
Data acquired from osmolality, glucose, and folic acid tests provides useful information for the specific identification of cell-culture media.
By Satish Mallya, Benjamin Lay, Lihong McAleer, Alexa…
Article
Platform Approach Speeds Process Development
…complex biopharmaceuticals such as recombinant monoclonal antibodies is dependent on high performing bioprocesses using mammalian host cells. Chinese hamster ovary (CHO)-based cell culture platforms …
Article
Going Small to Achieve Success on the Commercial Scale
He adds that there is a lot of effort being devoted to overcoming these issues to enable high-throughput modeling of downstream bioprocesses.
A few groups are also investigating the application of…
Article
Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
Surface plasmon resonance is helping define bispecific antibodies, the next-generation of biopharma therapeutics.
By Robert Karlsson
Abstract
Biotherapeutic antibodies are still the larg…
Article
Best Practices in Qualification of Single-Use Systems
Table II: General chemical incompatibility of these polymers with common fluids in bioprocessing* (see references 2-4).
In addition, pretreatment methods such as steam sterilization, e-beam irradi…
Article
Video: Xcellerex XDUO 2500 Single-Use Mixer
It is a robust, versatile, and easy to use single-use mixer that can be used for mixing operations throughout the entire bioprocess workflow. Watch video.
Article
Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
A study by BioProcess Technology Consultants estimated that approximately 70 mAb products could be on the market by 2020, which could be associated with up to £125 billion in sales (1).
Purifying …
Article
Breakthrough Drugs Raise Development and Production Challenges
Achieving fast approval of a breakthrough therapy creates challenges for manufacturers looking to develop CMC data in roughly half the time, noted Brian Kelley, vice-president for bioprocess developme…
Article
Advanced Technologies Facilitate Scale-up and Technology Transfer
“Many of these processes were licensed long ago and are quite complex, contain open steps, and are inefficient in many places,” notes Parrish Galliher, CTO of BioProcess Upstream at Cytiva.
FDA has…