Search results for " Mabs" in Articles / App Notes

Article Development of Purification for Challenging Fc-Fusion Proteins
Monoclonal antibody purification processes exist in different well-established platforms with extensive process performance histories for production of commercial mAbs (6-10), which typically consist …

Article Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
Several years ago, we started a development project to design and validate the next-generation protein A resin, MabSelect PrismA, which was just introduced to the market. Now, 1M NaOH can in fact be u…

Article Process Chromatography Selection for Downstream Processing Applications
Separation Technologies BioPharm: What are the most commonly used separation technologies for biologics that are not monoclonal antibodies (mAbs)? Björkman (Cytiva): If one excludes mAbs, then…

Article Top Tips for Successful Development of Antibody Chromatography Processes
If we look at how the mAbs were purified, it was mostly based on platforms. With the same process or with very small adjustment, you could purify multiple different targets or multiple different targe…

Article Cytiva Advances Fiber Chromatography Technology with New Launch
Using Ology Bio’s mAb platform, we have gained two orders of magnitude greater productivity using Fibro PrismA than MabSelect PrismA resin,” said Ryan Davis, senior scientist at Ology Biosciences, in …

Article Witnessing Major Growth in Next-Generation Antibodies
One involves technologies designed to improve the effector function and/or extend the half-lives of traditional mAbs through modification of the back end, or Fc (fragment crystallizable) region. “This…

Article Trends in BioPharma Approvals in 2013
In 2013,  20 products containing new biopharmaceutical molecular entities (defined herein as recombinant proteins, monoclonal antibody or biosynthesized nucleic acid-based products) were approved in t…

Article The Development and Application of a Monoclonal Antibody Purification Platform
The success of this platform in its various stages has been demonstrated for several MAbs representing different IgG classes produced in different cell lines. Recent advances in mam…

Article A Closer Look at Affinity Ligands
Bioprocess scientists and engineers realized the importance of affinity chromatography in purification of mAbs in the early 1980s and identified a small, 42 kD protein (i.e., Protein A) that has excep…

Article Setting Up Bioprocessing Systems for Digital Transformation
Digitalization of bioprocessing operations, equipment, and facilities can improve workflow and output, but maintaining data integrity is a concern. By Feliza Mirasol The advancement of digit…

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