Search results for " Mabs" in Articles / App Notes
Article
Process Chromatography: Continuous Optimization
Generally for mAbs, both strong CEX and AEX resins are preferred, according to Shelly Parra, global field applications senior manager with Thermo Fisher Scientific.
Mixed-mode and multi-mode resin…
Article
QbD and PAT in Upstream and Downstream Processing
It is important to note that mAbs are currently the leading area of biopharmaceutical research. One of the key parameters to monitor in the implementation of QbD in mAb production is the glycosylation…
Article
Advances in Engineering of Protein-Based APIs
Peptides and peptidomimetic therapeutics offer the advantages of mAbs but in smaller molecules that may be formulated for oral delivery.
Advanced modeling tools are enabling the rapid engineerin…
Article
Improving Process-Scale Chromatography
Thermo Fisher has introduced a new platform technology with large-scale production capability based on affinity chromatography resins that address challenges in the purification of mAbs, antibody frag…
Article
USP Publishes Monoclonal Antibody Guidelines
USP standards for mAbs
Currently, licensed monoclonal antibody (mAb) therapeutics include those involved in the activation of effector cells, cell killing, cross-linked induced apoptosis, antagonis…
Article
Leveraging Computational Models of Glycosylation for Biopharma QA
Man5 may also enhance antibody-dependent cellular cytotoxicity (ADCC) (8), a mechanism that improves the oncolytic activity of mAbs.
• Tandem α-1,3 galactose is a non-human glycosylation motif tha…
Article
ADC Development Robust Despite Lackluster Performance
Mersana is generating Fleximer-ADCs using mAbs provided by EMD Serono. Mersana will also conduct drug discovery and pre-clinical development activities, while EMD Serono will be responsible for clinic…
Article
Re-use of Protein A Resin: Fouling and Economics
A typical Protein A chromatography process consists of five steps: pre-equilibration and equilibration of the column; capture of the mAbs from the harvest; wash step with the selective buffer to remov…
Article
Next Generation Process Chromatography
The surface area that Fibro exhibits provides immediate binding opportunities at high capacities of the target proteins such as mAbs. This means that a chromatographic cycle that currently takes ~3 ho…
Article
A Look at the Affinity Chromatography Landscape
He points to engineered antibody affinity resins and mild-pH elution Protein A resins that enable elution of mAbs without the use of traditional, low-pH elution buffers as important examples.
“…