Search results for " downstream"
Article
Hybrid Bioprocessing: A Q&A with Andrew Sinclair
What could be the main reasons and/or the main drivers that hybrid bioprocessing are being used? Is there a difference between upstream and downstream?
If we look at the key benefits that are attr…
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Continuous Processing for the Production of Biopharmaceuticals
In the past few years, researchers have worked toward making various downstream unit operations continuous. While there is a plethora of emerging continuous bioprocessing technologies available in the…
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Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The white paper includes a brief discussion around modern vaccine processes, followed by a case study showing the scale-up of upstream and downstream processes for the production of a cell based live …
Article
A Closer Look at Affinity Ligands
…finity ligands and provide a deeper understanding of the role affinity ligands play in the future of downstream processing.
Breaking down affinity ligands
BioPharm: What are affinity ligands and …
Article
Updating Viral Clearance for New Biologic Modalities
Because viruses are typically smaller than downstream impurities such as host cell proteins (HCPs) and other extracellular debris, they require meticulous filtration, even in more established processe…
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Mapping a Route for Cell and Gene Therapy Process Development
…haracteristics, cell culture systems, and unit operations utilized in these processes, including the downstream methods employed to produce the final product. “The cellular characteristics (i.e., anc…
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Moving PAT from Concept to Reality
Changes in the bioreactor conditions during protein production will impact all downstream processes. In addition, the largest number of sensor technologies available for use in biologics manufacturing…
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Challenges of Protein Aggregation During Purification
…the cellular level has increased as titers have increased, if unsuitable conditions are selected for downstream operations, aggregation can also occur during downstream processing.
Aggregation me…
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Setting Up Bioprocessing Systems for Digital Transformation
…technologist, Biologics; Lukas Kuerten, senior scientist, Data Analytics; and Sean Ruane, scientist, Downstream. There is also the issue with data tracking, so that the components used are assigned t…
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Modeling and Miniaturization: Key Topics at Successful HTPD Conference
In the downstream space, the conference naturally covered chromatography, but also included a session about how HTPD approaches goes beyond chromatography. Jennifer Pollard from Merck, USA chaired the…