Search results for " downstream"
Article
Technology Innovations Improve Process Chromatography Performance
By Feliza Mirasol
Selecting an appropriate separation technology for biologic manufacturing is a crucial task in maximizing productivity in downstream bioprocessing. Biomanufacturers consider se…
Article
Unifying Continuous Biomanufacturing Operations
included the upstream and preliminary downstream steps of a monoclonal antibody (mAb) in 28 days, with the secondary downstream steps taking an additional two-and-a-half days (3).
A 1998 analysis …
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Continuous Manufacturing: A Changing Processing Paradigm
…Eric Langer, managing partner, BioPlan Associates—are manufactured through perfusion or continuous downstream processing, the field is evolving (1). Most of these processes are done piecewise, howeve…
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The New World of Biopharmaceutical Manufacturing
Single-use technology has also precipitated changes in upstream and downstream processing.
Pharmaceutical Technology spoke with Eric Langer, managing partner at BioPlan Associates; John …
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Biomanufacturing: Demand for Continuous Bioprocessing Increasing
And continuous processing downstream is still largely lacking and, where implemented, involves just a few of the many unit processes involved in downstream processing. Multi-column, countercurrent, an…
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CMOs Continue to Improve Overall Biomanufacturing Performance
Additionally, 41% reported at least some outsourcing downstream process development activities to some degree. Improvements in process development, therefore, are an encouraging sign for CMOs as this …
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The Challenge of Disruptive Technologies in Bioprocessing
Driving innovation
Drivers behind the development of disruptive downstream technologies include increase in demand for biologics. Demand for mAbs, for example, is expected to increase by one or tw…
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Evaluating the Use of Continuous Chromatography
In downstream processing, continuous chromatography is gaining traction in the purification of protein therapeutics. As the biopharmaceutical industry strives to demonstrate, continuous manufacturing …
Article
Innovative Chromatography Resins Can Improve Purity and Quality
With ongoing efforts to increase monoclonal antibody (mAb) productivity in large-scale biomanufacturing, biomanufacturers continuously seek advancements in downstream processing technologies, with dow…