Search results for " connected" in Articles / App Notes
Article
Moving PAT from Concept to Reality
On-line sensors are connected to process side streams and perform periodic automatic sampling, returning fluid back to the process streams after analysis is complete. At-line—or off-line—analyses invo…
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Achieving Process Balance with Perfusion Bioreactors
One way to simplify perfusion processes is to have the cell retention device closely connected to the perfusion bioreactor, yet have the flexibility to operate with multiple commercially available per…
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Making the Move to Continuous Chromatography
Continuous chromatography systems are designed to be loaded continuously, which is a useful approach when the purification step is connected to an upstream perfusion bioreactor. There are several diff…
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Improving Upstream Predictability
Univercells has leveraged process intensification in a new single-use bioreactor design that features a structured fixed-bed bioreactor connected to an automated tangential flow filtration concentrato…
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Integrated Semi-Continuous Process for mAb Production
Examples where two or more unit operations are connected and integrated are, therefore, of great interest for understanding the technical solutions as well as the approach for overall control.
Th…
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Digitalization: The Route to Biopharma 4.0
In periodic counter-current chromatography, sensor data from ultraviolet absorbance connected at the primary load column can be used to control column loading (21).
Advanced control systems …
Article
Track-and-Trace Progress Benefits Supply-Chain Security Efforts
By Agnes Shanley
The industry has made great strides in implementing serialization technologies, while technology developers are enabling more open access to real-time transportation data.
S…
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Strategizing for Rapid Changeovers in Biologics Manufacturing
Automation software can provide guidance in ensuring that a single-use flow-path is properly connected, thereby saving time performing manual validation, Shave adds. The software can also generate aut…
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Technology Innovations Improve Process Chromatography Performance
“The industry is moving towards intensified, connected, and continuous bioprocessing, and we expect about 30% of new molecules moving into clinical manufacturing will be based on intensified processin…
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Monitoring and Control of Inline Dilution Processes
Inline dilution (ILD) combined with inline conditioning (IC) is one of the key ways to intensify downstream processes, according to Avril Vermunt, program manager for connected biomanufacturing at Cyt…