Search results for "chromatography" in Articles / App Notes
Article
Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
If chromatography columns are used in the process flow, also specify the column volume and diameter required along with the desired number of cycles for each step.
Many single-use consumable suppl…
Article
Principles and methods for automated multistep protein purification
Principles of Automated Multistep Protein Purification
Summarized questions related to principles of multistep processing and the case study presented by Erwin van Puijenbroek and Matthias H…
Article
Your Reliable Downstream Bioprocessing. Our Proven AxiChrom Columns
The goal for biopharmaceutical manufacturers is to develop a process that will deliver material for clinical trials quickly and smoothly, achieve success in these trials, and scale up to commercial …
Article
Developing Cleaning-in-Place Protocols
Cleaning conditions for chromatography media can be screened in a couple of working days using 96-well microtitre plate formats. A study with a Protein A resin illustrates the approach in this appli…
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Tools for Continuous Bioprocessing Development
These experiments proved that modulation of input sources was possible, high-performance liquid chromatography (HPLC) sample collection times could be fast enough to look at dynamics, and control of o…
Article
Capto™ Core 700 in Vaccine Processing
The aim with this white paper is to discuss the advantages of using Capto Core 700 in virus purification compared to size exclusion chromatography (SEC), a technique commonly used in several vaccine…
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Best Practices in Qualification of Single-Use Systems
The author discusses the current best practices in technical qualification of single-use systems.
By Weibing Ding, PhD
Single-use technology has been around for approximately two decades if …
Article
Selecting a Comprehensive Bioburden Reduction Plan
Chromatography resins, for example, are not typically provided sterile or capable of being sterilized, so they are a potential source of contaminations unless cleaned, sanitized, and stored correctly.…
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Host-Cell Protein Measurement and Control
Other technologies, such as 2D-differential in-gel electrophoresis (DIGE), capillary zone electrophoresis-electrospray ionization-tandem mass spectrometry (CZE-ESI-MS/MS) or two-dimensional-liquid chr…
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Advanced Technologies Facilitate Scale-up and Technology Transfer
He adds that better-designed model bioreactor, chromatography, and filtration systems are allowing for even smoother scale-up and tech-transfer operations.
Raw material choices are also being adju…