Search results for "chromatography" in Articles / App Notes
Article
Purification of Plasmid DNA
By switching to modern chromatography resins, Cobra Biologics was able to increase binding capacity and flow rates up to 50% to address the increasing demands for high quality plasmid DNA.
Click h…
Article
Mapping a Route for Cell and Gene Therapy Process Development
…cts, such as digital droplet polymerase chain reaction, flow cytometry, and high-performance liquid chromatography, have enabled more consistent and accurate measurement of quality attributes, observ…
Article
Quality by Design in Biotherapeutics Purification: Understanding and Addressing Sources of Process Variability
Click here to download the white paper now >>
The principles and methodologies of biopharmaceutical manufacturing are well established today. However, the increased molecular diversity br…
Article
How to Adapt Biomanufacturing Processes
As the need for more complex molecules drives a new era of biomanufacturing, there is an increased focus on developing processes with improved security, yield, and process economy. Companies working…
Article
Methods Accelerate Biosimilar Analysis
For more detailed and accurate quantification of these modifications and to identify the sites where these modifications occur, however, it is necessary to perform peptide mapping by liquid chromatogr…
Article
Emerging Therapies Test Existing Bioanalytical Methods
… in vivo?
The assays used to measure these characteristics are often not traditional liquid chromatography–mass spectrometry (LC–MS) or ELISA used to quantify small- and large-molecule therap…
Article
Case Study: Virus Reduction of an Affinity Capture Step
Evaluating how much a process step contributes to viral clearance is an essential part of process validation. For this reason, there is an industry need to perform effective viral clearance studies. I…
Article
New HiScale™ 10/40 for Scale-Down Studies
Cytiva is pleased to announced the new HiScale™ 10/40.
HiScale 10/40 column is especially suitable for scale-down studies used in, for example, viral clearance evaluation in downstream processing. …
Article
New Guide for Packing HiScale, XK, and Tricorn Columns
This guide summarizes parameters for packing small-scale HiScale™, XK, and Tricorn™ columns with Capto and MabSelect resins from Cytiva.
Download the Packing Guide
Article
New Column for Scale-Down Studies
Cytiva is pleased to announce new Validation columns.
Their dimensions—narrow 10 mm inner diameter, combined with 20 cm bed height typically used in biomanufacturing—make these columns suitable …