Search results for "chromatography" in Articles / App Notes
Article
Handbook: Design of Experiments in Protein Production and Purification
Design of experiments (DoE) is a technique for planning experiments and analyzing the information obtained. The technique allows us to use a minimum number of experiments, in which we systematically v…
Article
The New World of Biopharmaceutical Manufacturing
Single-use sensors have been developed for a variety of process parameters for downstream steps such as chromatography, tangential flow filtration, direct filtration, and fill/finish, as well as for s…
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Column Tips for Successful SEC-MALS
Do you identify molecules using MALS, maybe in combination with size exclusion chromatography (SEC)? We have gathered Column Tips for Successful SEC-MALS in a blog post. Tap into these column …
Article
Extractables Studies for Single Use Systems Used in ADC Manufacturing, Part 1
To address those concerns, extractables studies were
performed on disposable chromatography column housings and disposable flow paths provided by Cytiva. The extractables studies were performed wi…
Article
Being Thorough When Transferring Technology
[In regards to chromatography steps], sometimes the linear flow needs to be lowered due to the volumetric flow restrictions in the large-scale facility. This would have to be tested during process opt…
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Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Traditional manufacturing processes for biologics make use of large, fed-batch reactors and oversized chromatography columns that end up wasting time or material. Alternatively, upstream process scale…
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How to Optimize Protein Desalting
But how do you determine which method to use? And how do you choose the right product for your needs? Learn more in this blog post about using size exclusion chromatography (SEC) for this purpose.
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Advancing Single-Use Technology Through Collaboration
The end-user can then determine the contribution of dilution, and removal steps such as [ultrafiltration/diafiltration] and chromatography, in reducing the calculated levels to below acceptable limits…
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High-Throughput Process Development Handbook
The handbook describes how results obtained using PreDictor plates can be used to define process conditions for large-scale chromatography. Applications of PreDictor plates are provided, as well as pr…
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A Q&A with Eric Langer: CMOs Embrace New Technology
In our 13th Annual Report of Biomanufacturing, of the 21 areas of innovation tested, we found CMOs more interested in: chromatography, single-use probes and sensors, disposable chromatography, instrum…