Search results for "chromatography"
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The Challenge of Disruptive Technologies in Bioprocessing
An example of the latter may be the use of affinity chromatography in the capture step of antibody processes, Jagschies says.
“When we look at the biologics market dynamics for treatment of dis…
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QbD and PAT in Upstream and Downstream Processing
…ace plasmon resonance (to assess product concentration and affinity)
•High-performance liquid chromatography (HPLC) (to assess product concentration and structure)
•Capillary electrophoresis …
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Discovering the unknown: How does in silico process development change PD scientists’ work?
Quickly, can you recap some of the main benefits of in silico process development? And then in a little bit more detail, can you shed some light on using mechanistic models that simulate and support c…
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Setting Up Bioprocessing Systems for Digital Transformation
Hahn points out that, for instance, pre-packed single-use chromatography columns of the same type may differ in terms of column packing and resin lot capacity. “In practical application, these differe…
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Going Small to Achieve Success on the Commercial Scale
…e therefore employed to determine optimum conditions for downstream separation processes, including chromatography and viral clearance steps. Qualification that such models provide results truly repr…
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Selecting the Right Viral Clearance Technology
In some cases, Riske notes that this inactivation step is incorporated into a chromatography method, such as in a solvent wash. “Column chromatography will frequently be effective for virus reduction,…
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A Q&A With Prof. Alois Jungbauer: The Role of HIC in Biotech
Maybe it was not as advantageous as first indicated?
At the conference there were presentations on multimodal chromatography. How do you value multimodal chromatography compared to HIC?
Multim…
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Download your Mechanistic Modeling eBook
The simulations are based on known physiochemical phenomena involved in chromatography. Mechanistic modeling is a mathematical representation of the physiochemical transport and interactions that occu…
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Process Development: 2020 Reflections and 2021 Possibilities
Speaking of game changers, Fibro chromatography, a recently launched chromatography platform, has been shown to enable purification cycles in minutes instead of hours. This results in higher throughpu…
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Monitoring and Control of Inline Dilution Processes
This issue must also be considered when ILD is used for chromatography and pH is a key operating parameter. In these cases, concentrate recipes should be characterized to consider the potential pH shi…