Search results for " media" in Articles / App Notes
Article
Fermentation for the Future
Reinisch also notes that media costs for microbial fermentation are lower, although media costs for cell culture have been declining. Drivers of new technology development in microbial fermentation ar…
Article
Innovations in Perfusion Bioprocessing
In this study, we present a method for deriving perfusion culture media by leveraging existing fed-batch media and feeds.
Furthermore, we illustrate the successful transfer of the develop…
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Top Process Development Trends for 2021 and a Look into 2022
… common to reach 3–10 g/liter as a result of high-producing cell lines, advanced technologies, and media, feeds, and process optimization. Lio details the manufacturing process, both cell line develo…
Article
Biomanufacturing: Demand for Continuous Bioprocessing Increasing
But that’s essentially the only continuous-adapted upstream unit process, with such things as culture media and additives preparation still done in batch processing. In some respects, perfusion has ov…
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Design Considerations for a Commercial Cell and Gene Therapy Facility
The technology in these fields is still far from mature, and a wide variety is seen in what is used, ranging from differences in equipment, media, and cell-expansion to even small parts such as tubing…
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Making the Move to Continuous Chromatography
He also notes that the advent of new membrane chromatography devices and chromatography media with hydrophilic base beads and high ligand densities will maximize the impact of continuous operations.
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Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
Next, if known, specify the buffer and media requirements of each unit operation step in the production process, including whether any solutions require special handling (e.g., 70% ethanol), if steps …
Article
Selecting a Comprehensive Bioburden Reduction Plan
Culture media treatment by high-temperature–short-time (HTST) or UV-C will reduce microbial load. Filtration may be used for cell-culture media or buffers. Chromatographic steps, low pH, and chemical …
Article
Fluid Handling in Biopharma Facilities
BioPharm: Which fluids represent the largest volumes within a facility?
Blomberg (Meissner): Typically within a biopharmaceutical manufacturing process that employs single-use systems, buffers and …
Article
Aseptic Processing: Keeping it Safe
Negative agency inspection, increasing operating costs, and poor media fill results are among the reasons many manufacturing organizations are deciding to update or replace aging aseptic processing eq…