Search results for "downstream" in Articles / App Notes
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Why use mechanistic modeling in downstream process development?
With mechanistic models, process developers can get a better understanding of both the entire process and the parameters that can …
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Create Digital Twins of your Chromatography Processes
GoSilico™ Chromatography Modeling Software creates digital twins of downstream processes using mechanistic models.
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Top Process Development Trends for 2021 and a Look into 2022
But many challenges are associated with the process development for the downstream purification of these molecules.
Peter Guterstam, Ph.D., product manager of next generation resins & technologies …
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Optimization of a Two-Step Purification Method for Bispecific Antibodies
Alligator and Cytiva developed an efficient downstream purification process for a cancer immunotherapy bispecific antibody (bsAb).
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Maximum Output Starts with Optimized Upstream Processing
CDMOs [contract development and manufacturing organizations] must provide flexibility to address bottlenecks, like taking the most streamlined path possible, decoupling upstream and downstream process…
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Efficient Sodium Hydroxide Sanitization with a Novel Procedure of AxiChrom™ Columns Packed with Chromatography Resin
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Sodium hydroxide (NaOH) cleaning-in-place is the widely accepted method of sanitization employed by biopharmaceutical manufacturers to avoid the excessive costs and delays of a…
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Common Challenges in Cross-Functional Process Development
Topic covered include:
1:28 – Common stumbling blocks in developing an effective bioprocessing operation
2:18 – Should upstream and downstream processes be developed concurrently or sepa…
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Basics in Process Development for Biotherapeutics
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Definitions, activities, and things to consider when developing an upstream or downstream bioprocess.
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High-Throughput Process Development in Biopharma
…Enables reduction of sample amount used
Explore how HTPD can help accelerate the development of downstream processes.
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Improving Upstream Predictability
“We’re seeing shrinking process footprints through continuous integration and connection of upstream and downstream processing,” he says.
The end result will be lower capital investment cost…