Search results for "downstream" in Articles / App Notes
Article
Introducing Process Characterization Kit: New Tools for Gaining Deeper Chromatography Process Understanding
With these insights, you can develop a solid control strategy for a robust downstream process.
Click here to learn more >>
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New Therapies Present Scaling Challenges
Dependence on single-use formats limits the selection of upstream hardware that is currently available, however; downstream hardware are more limited because processing solutions that are currently av…
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Design Considerations for a Commercial Cell and Gene Therapy Facility
…ogeneic cell therapy production) and characterized by larger single-use bioreactor skids with large downstream chromatography platforms, often segregated into two or more rooms. In mAb production, Ch…
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New HiScale™ 10/40 for Scale-Down Studies
HiScale 10/40 column is especially suitable for scale-down studies used in, for example, viral clearance evaluation in downstream processing. The small inner diameter (10 mm) and flexible adapters min…
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Single-Step, Protein A Chromatography Process for Bispecific Antibodies in Early Screening
BsAb constructs were efficiently purified to give more than 90% purity and 85% yield in the early screening downstream process.
Learn more about bispecific purification
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Making the Move to Continuous Chromatography
By allowing simultaneous operation on many columns, continuous chromatography is more efficient with time and resin, according to Michelle Najera, senior development scientist for downstream product d…
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Single-Use Chromatography: Adapting to Manufacturing Scale
While widely adopted in upstream production processes, what is required to move single-use technologies into downstream manufacturing scale?
This article discusses strategies for meeting the ever…
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Preclinical Evaluation of Product Related Impurities and Variants
The refolded samples were subsequently buffer exchanged and subjected to the downstream purification.
The choice of the purification platform is crucial for this study. The platform should be …
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Techniques for Improving Process Development for Exosome-Derived Therapeutics
Here, the Process Development Forum speaks with Aaron Noyes, Head of Downstream Processing, at Codiak BioSciences about exosomes, their potential clinical applications, and process innovations that wo…
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Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
Increasing upstream titers can make the Protein A chromatography process step the rate-limiting step in downstream purification. Protein A chromatography columns are frequently too large, limiting the…