Search results for " platform"
Article
Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
…ell as the operational aspects of combining process hardware, single-use consumables, and automation platforms.
Overall, there are four sets of requirements to consider: product(s) to be made, pr…
Article
Continuous Processing for the Production of Biopharmaceuticals
Effectively, the configuration can significantly contribute to the development of an integrated continuous bioprocessing platform for bacterial recombinant proteins.
Figure 1: (a) Illustration of …
Article
High-Throughput Process Development in an Historical Environment
In the presented work, instead an automated platform using 96-well plates for parallel screening of inclusion body solubilization and protein refolding conditions was shown. With this approach, 24 sol…
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Relationship Building at Top of Mind for Clients
By contrast, factors that have become crucial to fewer respondents over the years include having production platforms relevant to the client’s product. This is likely due to most CMOs having probably …
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Defining Critical Quality Attributes for Monoclonal Antibody Therapeutic Products
For platform molecules, or new products with structural homology to established classes (e.g., Fc fusion proteins, pegylated proteins), the team can leverage information from related proteins. Convers…
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Best Practices in Adopting Single-Use Systems
As the case continues to build for end-to-end disposable bioprocessing, bioprocessors should be aware of the key factors associated with implementing single-use components or platforms. Potential adop…
Article
Automated Concentration and Diafiltration of Multiple siRNA Samples
PROCESS DESCRIPTION
The production of RNA oligonucleotides in the process workflow begins with chemical synthesis using the ÄKTAoligopilot platform to create single-stranded RNA (ssRNA)…
Article
Future-proof your AAV process with a complete producer cell line – just induce and grow
We describe such an all-inclusive cell line platform that can be customized for your specific GOI and capsid. Just add the induction agent, and you’re ready to go.
In this webinar:
• Discover th…
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Evolving demands of process development services
But the CDMOs will need a large R&D team with the right expertise and a broad technology platform to ensure the most appropriate chemistry at every scale.
The final trend that is being seen and, i…
Article
Top Process Development Trends for 2021 and a Look into 2022
… when it comes to process development, both from an upstream perspective—such as which development platform to use and scalability—and a downstream perspective—such as cell lysis and the polishing st…