Search results for " platform"
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Virus-like Particles as Therapeutic Moieties of the Future
Attempts have been taken to widen the spectrum coverage of VLP-based vaccine using chimeric systems, such as by adding a new epitope on existing VLP platforms (24).
Development of a VLP-based v…
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Akron Bio Will Install a Cytiva FlexFactory to Manufacture Plasmid DNA
Cytiva will provide its FlexFactory, a flexible, single-use platform, to enable Akron Biotech to manufacture plasmid DNA (pDNA), which is used in many innovative therapies and vaccines, Cytiva said in…
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Reimagining Affordable Biosimilars
Exponential advances in new technologies and computing such as mathematical modeling of pharmacokinetics (PK) and pharmacodynamics (PD), organ-on-a-chip platforms, in-silico algorithms, and transgenic…
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Eliminating Residual Impurities Starts with a Strategic Plan
For example, he notes that if a platform drug substance downstream process has shown for different platform molecules that a supplement added during fermentation can be depleted to a satisfactory leve…
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Impurity Testing of Biologic Drug Products
The guideline for all phase appropriate levels would be the International Council for Harmonization (ICH) Q2 (R1) (1), although different technical platforms (e.g., enzyme-linked immunosorbent assay […
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ADC Development Robust Despite Lackluster Performance
The candidate is built on the company’s lead ADC platform, Dolaflexin, which consists of a biodegradable, biocompatible, and water-soluble polymer, called Fleximer, and multiple molecules of the compa…
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Improvements in Protein A Chromatography
The Protein A step is platformable so that the same buffers and conditions can be used for many different clinical antibody candidates. This allows for fast step development. Alternative technologies …
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Witnessing Major Growth in Next-Generation Antibodies
“Novel antibody platforms have primarily been applied to cancers because immunogenicity and potential unforeseen clinical effects that might be better tolerated for cancer treatment than for chronic t…
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Reconciling Sensor Communication Gaps
The desirability of platform purification, best exemplified in monoclonal antibody (mAb) downstream processing, simultaneously creates and reduces the need for extensive downstream monitoring. Platfor…
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Generating a Fully Processed Antibody
…d by Chinese hamster ovary (CHO) cells, and more recently, numerous different multispecific antibody platforms. Each of these classes of molecules requires multiple proteins to be expressed at differ…