Search results for "bioreactors" in Articles / App Notes
Article
Best Practices for Selecting a Top-Quality Cell Line
Before scaling up to bioreactors, the productivity level for monoclonal antibodies (mAbs) should be 2–7 g/L (fed-batch culture in shake flask) or greater, observes Selexis CEO Igor Fisch. Once scaled …
Article
Ensuring Viral Safety of Viral Vaccines and Vectors
Extraneous vesiviruses, however, have recently appeared in bioreactors (2–5), and porcine circovirus type 1 (PCV-1) contamination of oral rotavirus vaccines was first reported by a metagenomics analys…
Article
Optimizing Late-Stage and Commercial Cell-Culture Processes
He also anticipates seeing more complex processes and smaller, single-use technology bioreactors for production. “Accelerated clinical development becomes more common and faster, leading to very short…
Article
Challenges in Cell Harvesting Prompt Enhancements
Biomanufacturers have been shifting from large stainless-steel bioreactors in the thousands-of-liters range to smaller, disposable bioreactors (2).
The need to address this bottlenecking issue …
Article
Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
For example, one can consider 2 x 2000-L bioreactors running a typical 14-day incubation period staggered a week apart, which equates to one batch produced each week. A typical batch at 2 g/L with a 7…
Article
A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
…ization, many of these studies are performed using cells grown in shake flasks or small bench-scale bioreactors under nonoptimized cell culture conditions. Therefore, it is crucial to further evaluat…
Article
Implementation of Raw Material Control Strategies in the Manufacture of Single-Use Bioprocessing Containers
The authors review efforts to limit polymer degradation without significantly impeding cell growth.
Jan 01, 2015
By Sara Ullsten, Shujian Yi, Jeffrey Carter, Eva Lindskog, Pokon Ganguli, Her…
Article
Improving PAT for Biologics
The complexity of biopharma processes requires innovative solutions.
Dec 01, 2014
By Cynthia Challener, PhD
BioPharm International
A key component of the quality-by-design (QbD) ap…
Article
Stirring up the fermentation game
Bioreactors designed for production in mammalian culture fall short of meeting these unique requirements, for example in terms of oxygen transfer capacity and temperature control. The Xcellerex XDR-50…
Article
Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
This case study shows that single-use equipment, including disposable cell culture bioreactors, pre-packed chromatography columns, and filters, can replace traditional equipment, including stainless s…