Search results for "bioreactors" in Articles / App Notes

Article Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
…e quantities of cells in a very short period of time and then using that to either inoculate larger bioreactors or run in a continuous manner. That's where PAT comes in handy. Raman is the prim…

Article New Therapies Present Scaling Challenges
Bioreactor size can be increased (scale up), or the number of bioreactors used can be increased (scale out). In addition, mammalian cell culture technology has advanced such that producing multi-kilog…

Article Industry Adoption of Single-Use Systems Remains Low
“It is far more common today that biopharma manufacturers are building small economical facilities with several 2000-L single-use bioreactors--20 years ago, the companies were building a facility with…

Article Flexible Facilities for Viral Vector Manufacturing
Makowiecki explains that vector production using adherent cells in fixed-bed bioreactors is limited in scale primarily by the size of the fixed-bed bioreactors, and scale-out is used to increase produ…

Article Making the Move to Continuous Chromatography
If a manufacturer can reduce its process to a 2000-L bioreactor, or multiple 2000-L bioreactors, facilities become much easier to build with shorter construction times and reduced cost. In this case, …

Article Hybrid Bioprocessing: A Q&A with Andrew Sinclair
With the improvements and the rise of SU equipment bioreactors, containers, and physical transfer, a lot of the complexity is removed and even with some reusable equipment, we can still achieve the fa…

Article Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
First, the availability of high-throughput miniature bioreactors has made it possible to evaluate many more conditions. This has enabled design of experiment (DoE) approaches, such as response surface…

Article Best Practices in Qualification of Single-Use Systems
Aseptic connector devices, mixer bags, storage bags, and bioreactors followed. Currently, single-use systems (SUS) also include disconnectors, disposable filling needles, and sensors. The technology i…

Article Evaluating the Use of Continuous Chromatography
…t or sometimes over 24 hours, the larger volumes processed continuously from perfusion or fed-batch bioreactors must be processed over several weeks or up to a month. [This] can make it more difficul…

Article Simplify-bioreactor scale up and scale down: applications and tools
Scaling the physical environment in a bioreactor is a frequent task in each product development project. A well-designed scaling strategy, workflows, and easy-to-use tools will facil…

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