Search results for " yield" in Articles / App Notes
Article
Biopharma Manufacturers Respond to Ebola Crisis
Increasing the drug’s production yield involves expanded use of tobacco leaves for antibody production in a system operated by Kentucky BioProcessing (KPB), a unit of tobacco giant Reynolds American. …
Article
Using Quality by Design to Develop Robust Chromatographic Methods
…or software, which allows for a more thorough understanding regarding the most suitable pH that will yield a more robust separation.
Experience with this systematic approach to method development…
Article
Challenges and Trends in Biopharma Facility Design
…l it at all get to market?
• Market demand
• Size and frequency of doses
• Process yields
• Manufacturing challenges and innovations
• Cost and schedule pressure
• Globalizati…
Article
Challenges of Protein Aggregation During Purification
“In particular, resolubilization of insoluble aggregates typically requires extra process steps and can both be very costly and compromising on the overall process yield,” adds Jagschies.
Changing…
Article
A Q&A With Phil Lester, co-organizer of the HTPD Conference
The goal is to purify the target protein to the highest purity and yield, using the most efficient workflows and fewest resources. We have six teams competing—they began work in January and will finis…
Article
Quality by Design—Bridging the Gap between Concept and Implementation
These companies have seen increased production efficiencies and yields as a result, with fewer off-specification outputs and a decrease in production recalls. Some of the leading pharmaceutical compan…
Article
Predicting Progress in Protein Aggregation
“Cells may stop secreting a protein if it takes on a new, aggregated form, leading to low titers and reduced yields and productivity. In addition, the formation of larger precipitates can cause the ph…
Article
Evolution of the Monoclonal Antibody Purification Platform
When implemented for a specific product, the revised elution scheme led to a 5% absolute reduction in fragment content with a 10% yield loss.
Gradient elution for cation exchange chro…
Article
Trends in Downstream Bioprocessing
So the issue is, what can we do to increase the concentration of protein in solution without decreasing yields or activity?”
On-going research into new technologies being developed in this industr…
Article
Operational Excellence: More Than Just Process Improvement
Such transformations can yield a multiplicity of operational, organizational, and financial benefits that can be leveraged and sustained into the future. Not the least of these sustainable benefits ar…