Search results for " buffers" in Articles / App Notes
Article
Process Development: 2020 Reflections and 2021 Possibilities
These approaches include pre-weighed, ready-to-dispense solid packaging systems, ready-to-use diluted buffers, and others.
Bioprocess Development Forum readers also focused on upstream predictabil…
Article
Scaling Up Novel Therapies
Prime examples, he says, are recipes with long and shallow linear gradients, as well as pH specifications for process buffers that can only be achieved off-line in the lab. Developers may also use a w…
Article
Reducing Cross-Contamination Risks in Process Chromatography
Changes in extractable and leachable profiles for contact materials when exposed to process buffers for several days, weeks, or even months in a fully continuous process workflow must also be addresse…
Article
Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
This week Process Development Forum talks about Protein A with Jonathan Royce, business leader for Cytiva chromatography resins.
mAb purification platforms are very well established, and …
Article
Process Chromatography: Continuous Optimization
“In addition to these opportunities to optimize performance, it is also important to look at improving the overall ecosystem around the chromatography process, by considering the buffers, cleaning age…
Article
The New World of Biopharmaceutical Manufacturing
Today, buffers are held in bioprocess containers and unit operations are connected with tubing. Chromatography columns can be disposable or can be replaced by single-use membrane adsorbers. In the pas…
Article
Evaluating E&L Studies for Single-Use Systems
Extraction studies demonstrate approaches for evaluating single-use bio-pharmaceutical manufacturing materials.
By Irene Cecchini, Daniele Mastroianni, Silvia Rocchi, Gabriella Angiuoni
Biop…
Article
Downstream Processing Continues to Worry CMOs
CMOs are working hard to improve performance by investigating new technologies for filtration and purification.
By Eric S. Langer
Downstream processing continues to be a significant pain poi…
Article
An Integrated Approach to Ensure the Viral Safety of Biotherapeutics
• Other raw materials including formulation buffers can be nanofiltered (20-nm pore size) as liquid solutions.
Building viral safety into a quality system
Effective virus r…
Article
Continuous Processing for the Production of Biopharmaceuticals
The authors review the technologies that may help bioprocessing become a truly continuous operation and present case studies that could contribute to the integration of upstream and downstream platf…