Search results for " buffers"
Poster
Scale-up and process economy calculations of a dAb purification process using ready-to-use products
In addition, process economy of using ready-to-use equipment and ready-made buffers versus using reusable equipment and in-house prepared buffers was compared. A three-step dAb purification process wa…
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
Newer classes of biotherapies will require innovations in processing technology.
By Glen R. Bolton, Bernard N. Violand, Richard S. Wright, Shujun Sun, Khurram M. Sunasara, Kathleen Watson, Johna…
Article
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
A major advantage of SPR-based analysis is its ability to estimate the association and dissociation rate constants, an …
Article
The Challenge of Disruptive Technologies in Bioprocessing
“We see end-users transitioning away from internal manufacturing of downstream processing buffers and focusing on core activities; they are looking to outsource these non-core activities to ease the b…
Article
Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
The objective of this study was to assess the impact of manufacturing-scale, freeze-thaw conditions on aggregation and subvisible particle formation of a monoclonal antibody solution (mAb-A; IgG1) u…
Article
Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
One hot article answered two commonly asked questions about in-line buffer preparation, which were “Will our buffers work?” and “How can we be convinced that buffers are made to specification?”
…
Article
Driving Change in Biomanufacturing
Whatever the objective, driving change is a challenge. Implementing a new technology into a bioprocess is a big change. The new technology must be fully understood, all regulatory requirements fulfi…
Article
Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
Asking the right questions is crucial to establishing a facility design.
By Peter Genest, John Joseph
The benefits of adopting single-use technologies in the production of biopharmaceuticals…
Article
Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
For our study, these benefits enabled decreased number of buffers needed. The possibility to serially connect Capto Q and Capto Core 700 media columns allows for enhanced system utilization and a redu…
Article
Connected Inline Conditioning for Better Process Efficiency
In this study, we integrated an inline conditioning (IC) system that served as a buffer preparation skid with chromatography and filtration systems. This automated the buffer preparation p…