Search results for " lab-scale" in Articles / App Notes
Article
How to Pack Lab-Scale Columns
See below for resources and tips for how to usefully pack lab-scale columns.
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Article
How to Pack Lab-Scale Columns
Watch how-to videos >>
Learn how to pack Tricorn™ and XK chromatography columns. Our new video tutorials show step-by-step instructions for a well-packed column.
Article
Using Digital Twins to Model Process Chromatography
Models are typically calibrated using lab-scale data for material and cost efficiency, with the model then scaled to predict manufacturing scale by accounting and simulating changes to scale, operatio…
Article
Connected, Automated Downstream Process for mAb Screening and Evaluation
This study was done to show both proof of principle for an automation solution for a lab-scale protein purification set-up, and that it would significantly decrease hands-on time, while assuring that …
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Your Protein Purification Questions Discussed
In one of Cytiva´s web chats, ÄKTA™ system users asked questions relating to lab-scale protein purification and ÄKTA systems, which experts answered during a live session.
The expert…
Article
Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
Figure 3: Selectivity between monoclonal antibody (mAb) monomers and aggregates at a higher sample load following the optimized first polishing step in a lab-scale column, showing the percentage of fr…
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Enhancing Resins Addresses Purification Concerns
In lab-scale processing, lithium chloride precipitation may work well, but scalability of such a process is poor, Deorkar states. Affinity chromatography, such as oligodT is commonly used for a captur…
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Process Development: 2020 Reflections and 2021 Possibilities
More Popular Articles of 2020
The following are some of the year’s best articles from Bioprocess Development Forum:
Purification of Plasmid DNA
How to Pack Lab-Scale Columns
Gene The…
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Protein Purification Questions and Answers from ÄKTA Club Web Chat
Web chats, where Cytiva experts answer questions about protein purification and ÄKTA lab-scale systems during a live session, are recurring events within ÄKTA club.
Questions and answers…
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
Step 4: Model validation
Model validation can be performed by using a lab-scale column of the same bed height as in a commercial column and running it at various protein loadings to cover the …