Search results for "antibody" in Articles / App Notes
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
In a study (4) that used modeling software to evaluate commercial monoclonal antibody (mAb) production, it was shown that the unit operation cost was 19% to 33% less for a membrane process used on 100…
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An Analytical Approach to Biosimilar Drug Development
For immunogenicity assays, the current industry practice is also to use a single assay, with the biosimilar as a capture reagent (and as the conf irmatory drug) when assessing antidrug antibody (ADA) …
Article
Why, Why, Why…ELISA? A Look at the Benchmark HCP Assay
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Biologics developers and manufacturers demand an accurate and reliable assay for host cell protein (HCP) quantitation. Let’s take a close look at why analytica…
Article
Nurturing Knowledge from Disparate Data Streams
Anderson points to antibody-drug conjugates (ADCs) as an example. “ADCs comprise an antibody, a small-molecule cytotoxic payload, and a linker of some kind, which can be an oligomer or other small to …
Article
News: Cytiva Adds ELISA Kit to End-to-End HCP Monitoring Capabilities
Cytiva is pleased to announce the new Amersham HCPQuant CHO kit, a generic for detecting host cell protein impurities in drug samples produced in CHO cell lines.
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Article
Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
Numerous readers also explored semi-continuous processing, specifically an application note about how various unit operations in a laboratory-scale monoclonal antibody (mAb) process can be connected a…
Article
Perfusion Culture Using TFF or ATF as Cell Retention Method
The work demonstrates perfusion culture of an antibody producing Chinese hamster ovary (CHO) cell line, using either tangential flow filtration (TFF) or alternating tangential flow filtration (ATF) as…
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Scalable Viral Vector Manufacturing
The interest for robust and scalable viral vector manufacturing is rapidly increasing, with the recent developments of both cell and gene therapy and oncolytic virus-based therapies. As cost pressur…
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Ensuring Viral Safety of Viral Vaccines and Vectors
Cell lines must also be tested for species-specific viruses, as appropriate, using antibody tests or polymerase chain reaction (PCR) panels.
Figure 3. Test strategy for ensuring cell banks and …
Article
Putting Viral Clearance Capabilities to the Test
Process understanding and careful assessment of risks are essential in developing viral clearance programs.
By Rita C. Peters
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