Search results for "cho" in Articles / App Notes
Article
Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
…ycles
• Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
• How to Determine Dynamic Binding Capacity (DBC) of Chromatography Resins
Article
Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
Trends in adoption of diverse mammalian expression systems have also not materialized, as Chinese hamster ovary (CHO) cell lines have become the dominant expressions systems. In fact, nearly 80% of re…
Article
Exotoxin Clearance from mAb Samples in a Two-Step Chromatography Process
A heat-stable exotoxin can remain as a contaminant of a drug substance throughout the whole manufacturing process, with the risk of adversely affecting patients’ health. One such toxin is cereulide …
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Ensuring the Biological Integrity of Raw Materials
He points out that reliance on Chinese hamster ovary (CHO) and other non-human cells is more of a problem. “Cross-species contamination for a virus is fairly low,” Elhofy said. “There’s still the risk…
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Biopharma in 2016: Higher Quality Drugs, Less Expensive Manufacturing
…wnstream Process Intensification
A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
A Second Modular Biopharma Facil…
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Modeling Bioreactor Performance
“The real work is building the model within whichever tool is chosen,” he states.
Meeting modeling challenges
Challenges to successful modeling come from technical and resource limitations. On…
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Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
But because the chosen methods focused primarily on downstream virus removal or inactivation instead of strategic sourcing of lower-risk starting materials, the efforts had little effect on serum-free…
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A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
…five different chemically defined components of cell-culture media used in a Chinese hamster ovary (CHO) cell manufacturing process for recombinant proteins (11). Although, both NIR and Raman spectro…
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Continuous Processing for the Production of Biopharmaceuticals
The high-density Chinese hamster ovary (CHO) cells were operated at a quasi-steady stage for more than 60 days. The PCC system was directly integrated into this and ran continuously for 30 days. Produ…
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Antibody Production in Microbial Hosts
Mammalian cells have been primarily applied as the hosts of choice for mAb expression. However, clinical success of mAbs has tremendously increased their demand, and this in turn has fueled interest i…