Search results for " capture" in Articles / App Notes
Article
The Outlook for CMO Outsourcing in 2019
BioPlan expects Chinese CMOs to capture business, potentially doing this at the expense of Indian CMOs. India appears to be focusing on serving its own and international markets for lesser-regulated b…
Article
A Look into the Future of Biopharmaceutical Quality
By the time updates are made to the pharmacopeias to capture the current technological advancements, more sophisticated equipment and methodologies are being introduced.
The industry seems to b…
Article
Integrated Semi-Continuous Process for mAb Production
In brief, the mAb process consists of perfusion cell culture, continuous capture chromatography, viral inactivation (VI), post VI filtration, batch polishing chromatography, and a final pH adjustment …
Article
Selection Guide: Columns and Resins for Antibody Purification and Immunoprecipitation
Polyclonal antibodies, monoclonal antibodies (mAbs), and antibody fragments are usually purified by affinity chromatography. Resins containing an immobilized ligand (e.g., protein A, protein G, or p…
Article
Cleaning Protein A Resins with 1 M NaOH
The presence of cell culture nutrients in the harvest feed loaded on the capture column also exposes the protein A step to increased risk of microbial contamination. Historically, protein A resins hav…
Article
Applying GMPs in Stages of Development
It also helps to capture the product and process history needed in the later phases of development for the process validation activities.
To determine the impact of the deviation on the …
Article
Navigating Data Integrity in the Modern Lab
The technology of the past decade has allowed for better preservation of data, from the time of capture in electronic format through to its analysis and use in reports.
This digital thre…
Article
Preclinical Evaluation of Product Related Impurities and Variants
…t the number of fractions used in the analysis represents sufficient variability that is adequate to capture the impact of the variants on the activity. Second, keeping roughly the same amounts of ac…
Article
Reducing Cross-Contamination Risks in Process Chromatography
Bulpin notes that single-use chromatography affinity solutions will enable rapid cycling chromatography and continuous capture at high speed. To address the industry need for continuous processing, Mi…
Article
Modeling and Miniaturization: Key Topics at Successful HTPD Conference
Walther presented a miniaturized and parallelized downstream process consisting of mechanical cell disruption, IB wash, protein renaturation, and capture chromatography carried out in 96-well plates, …