Search results for " capture"
Article
A scalable single-use two-step plasmid purification process
The current global demand for biopharmaceuticals is over USD 300 billion, with an estimated growth of ≥ 12% annually. While MAb processes have become much more efficient, production of mRN…
Article
Chromatography processes for the diversified therapeutic antibody pipeline
The diversity of antibody variants in today’s pipeline presents unique challenges for purification and we see molecules such as bsAbs, Fabs, dAbs, and others. Conventional chromatography protocols, …
Article
Fundamentals of hydrophobic interaction chromatography
Hydrophobic interaction chromatography (HIC) is a versatile technique that can be used for capture, intermediate purification, or polishing steps.
This technique separates proteins accor…
Article
Optimization of a two-step purification method for bispecific antibodies
Bispecific antibodies (bsAbs) have gained increasing interest over recent years because they can bind two antigens, offering unique modes of action compared to monoclonal antibodies. New and i…
Article
Current Techniques and Challenges Presented in Scaling Between Bioreactors
…dreas Castan: The organizations which includes CMOs have acquired elaborated template available that captures the critical information, and operating parameters for the transfer process related infor…
Webcast
Find the Right Intensification Strategy for Your Upstream and Downstream Processes
Learn more from our process intensification experts on how to approach your upstream bioreactor operations and downstream capture in our free webinar.
Article
Alkaline stability of Fc and VH3 binding in protein A resins
In the development of antibody purification protocols, you need to know your Ab molecule and its possible affinity binding sites for the chromatography resins. In this study, we have looked at…
Article
Optimization of a Two-Step Purification Method for Bispecific Antibodies
Alligator Bioscience AB develops antibody-based pharmaceuticals for cancer treatment, specializing in mono- and bispecific antibodies for tumor-directed immunotherapies. Alligator and Cytiva devel…
Article
Webcast on Demand: Find the Right Intensification Strategy for Your Upstream and Downstream Processes
Learn more from our process intensification experts on how to approach your upstream bioreactor operations and downstream capture in our free webinar.
Click here to register now >>
Article
Explore the Process Intensifier App
• Downstream capture (protein A step) operations: explore the possibilities of high-capacity resins, Fibro rapid cycling, and continuous multicolumn chromatography.
• Both as a connected operati…