Search results for " harvest" in Articles / App Notes
Article
Mixing dynamics in a large volume single use mixer
Upstream applications such as medium preparation and harvest require fast and efficient mixing whereas downstream mixing operations used in purification and separation processes require sensitive mi…
Article
Process Chromatography Selection for Downstream Processing Applications
BioPharm: What are some new separation technologies available for downstream processing?
Becerra-Arteaga (MilliporeSigma): In the harvest steps, the use of precipitation and flocculation technique…
Article
Downstream Processing Continues to Worry CMOs
…to shorten cycle times
• Investigating alternatives to protein A
• Developing more efficient harvest/flocculation operations
• Investigating non-chromatographic separations (e.g., aqueous two-p…
Article
Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
Moving to downstream, the overall yield of the purification process from post-cell culture harvest through to purified bulk API should be provided, along with an estimate of the step yield of each uni…
Article
Taking a “Development-by-Design” Approach to Cell Therapies
to use its Mobius bioreactor platform to expand and harvest HepRG cells. Cytiva is also evaluating Wave and other systems and set up a center of excellence in Wales recently.
In other equipment ar…
Article
Biosimilars Will Bring Significant Litigation and Patent Challenges
May 04, 2015
By Randi Hernandez
The risks involved with patent suits may become a bit more undesirable, thanks to new legislation aimed at deterring unreasonable patent suits. A senate bill…
Article
Modular Manufacturing Platforms for Biologics
While large-scale bioreactor systems may require a traditional facility design, he says that once harvest volumes are concentrated via ultrafiltration, podular processes can resume. “Because it is com…
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Improving PAT for Biologics
Sartorius recently extended its bioreactor portfolio with automated glucose-feed-control and integrated real-time measurement of viable cell density for automated induction, infection, and harvesting …
Article
Application of Quality by Design to Viral Safety
It did detect, however, significant differences between feedstocks, limiting the general applicability of its findings to different cell culture harvest substrates. For anion exchange chromatography, …
Article
Best Practices in Adopting Single-Use Systems
Key considerations for implementing single-use components or platforms when moving from research to process development.
The adoption of single-use systems in biopharmaceutical production or…