Search results for " protein"
Article
Affinity Chromatography Handbook: Vol. 1 Antibodies
The use of recombinant technology opens up the potential to create an infinite number of combinations between immunoglobulins, immunoglobulin fragments, tags and selected proteins, further manipulatin…
Article
Platform Approach Speeds Process Development
…uctivity and overall product yields in a biopharmaceutical process for the production of recombinant proteins.
At Boehringer Ingelheim (BI), advances have enabled higher performance benchmarks in…
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Continuous Processing for the Production of Biopharmaceuticals
The dynamic mixer at the beginning of the reactor configuration provides the rapid mixing that is required during addition of reduced protein to the refolding buffer, and the CFIR provides constant mi…
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Developing Cleaning-in-Place Protocols
A study with a Protein A resin illustrates the approach in this application note.
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ÄKTA Laboratory-Scale Chromatography Systems Handbook
This handbook is focused on liquid chromatography systems used for protein purification at research laboratory scale. Beginners can use the handbook to obtain an overview of how purification systems…
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Labeling of Biosimilars
In December 2014, guidelines on quality standards for biosimilars with proteins as an active substance came into effect (1), while guidance on clinical and non-clinical issues with the products was be…
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Technologies and Practices Must Evolve to Meet Demand
Respondents to the 2015 survey who develop or manufacture protein-based drugs expressed less concern about protein stability challenges than their counterparts did in 2014. Regulatory issues and micro…
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A Q&A With Phil Lester, co-organizer of the HTPD Conference
For the Olympiad, Cytiva created a kit containing a target protein in a crude feedstock along with a variety of chromatography media and suggested analytical methods. The goal is to purify the target …
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Trends in BioPharma Approvals in 2013
Like Genentech’s already well-established product Rituxan (rituximab), Gazyva targets the CD20 surface protein associated with B lymphocytes and is approved to treat chronic lymphocytic leukaemia, one…
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Bioprocessing Advances in Vaccine Manufacture
coli) for recombinant protein expression are further making vaccine manufacture easier and cost-effective and reducing the scale and investment required to manufacture products. The BioPlan annual sur…