Search results for " protein"
Poster
Strategies for optimized cell culture media: Effectively using design space to influence product quality
Balancing the many individual media components required to achieve high titers and support critical protein quality attributes can be challenging. Here we highlight a statistical design strategy to op…
Poster
Fast Trak Services: a collaborative project to accelerate downstream biosimilar process development
One of the biosimilar specialties present in mAbxience pipeline constitutes an Fc-fusion protein, with a molecular weight of Mr 150 000 and an isoelectric point of < 5, for which a first-generation p…
Poster
Collaborating to address the bioburden challenge
For example, development of Protein A resins to withstand high NaOH concentrations and investigations of an oxidizing agent for sanitization are conducted.
Article
Reconciling Sensor Communication Gaps
For most of the history of the biomanufacture of therapeutic proteins, in-process measurement and control focused on upstream operations. Historically, cell culture and fermentation persist longest am…
Article
Simplify chromatography method creation
Method creation is an essential part of preparing for automated protein purification runs. To save time and effort, method creation can be simplified and you can get to the point where you can start…
Article
Downstream Processing Continues to Worry CMOs
Meanwhile a much larger proportion of respondents are investigating alternatives to protein A (27.6%) than actually switching to alternatives (6.6%), with this trend holding true for several years now…
Article
Microbiological Testing: Time is of the Essence
Next-gen therapies have unique needs
The lengthy time to obtain results for traditional microbiological test methods, while not a technical issue for more stable proteins, antibodies, and other old…
Article
Design and Qualification of Single-Use Systems
Much of SUT use occurs in therapeutic protein API production. International Council for Harmonization (ICH) Q7, European Medicines Agency (EMA) Q7, and FDA
Q7A Good Manufacturing Practice Guidance…
Article
Selection Guide Size Exclusion Chromatography Columns and Media
A variety of media with different selectivities are available and cover a molecular weight range from Mr 100 to 100 000 000, from peptides to very large proteins, protein complexes, and virus.
D…
Article
Connect Alias™ Autosampler to ÄKTA™ Pure or ÄKTA Avant
When working with a large number of small volume samples, sample injection into your protein purification system can be tedious and time consuming. To minimize manual injections and save time, an auto…