Search results for "perfusion" in Articles / App Notes
Article
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
Perfusion continues to be one such operating mode that lends itself to adding benefit at the manufacturing scale while adding complexity to the small-scale approach.
Article
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
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We have developed a reliable small-scale model for a monoclonal antibody (mAb) perfusion process using TPP® TubeSpin® Bioreactor tubes and the ReadyToProcess WAVE 25 R…
Article
Tools for Continuous Bioprocessing Development
However, continuous culture operation, in all its forms--chemostat, turbidostat, and perfusion--can support metabolic flux analysis for increased process understanding (see sidebar). Continuous perfus…
Article
Continuous Manufacturing: A Changing Processing Paradigm
While only a few approved biologic products in the market—less than 10%, according to estimates by Eric Langer, managing partner, BioPlan Associates—are manufactured through perfusion or continuous do…
Article
Unifying Continuous Biomanufacturing Operations
Currently, approximately 20 FDA-approved biologic products are made using perfusion, according to a comment during INTERPHEX 2017 from Parrish Galliher, chief technology officer, upstream, at Cytiva. …
Article
Biomanufacturing: Demand for Continuous Bioprocessing Increasing
Continuous processing upstream has been around for decades as perfusion (e.g., fiber-based perfusion bioreactors for fused-cell hybridoma culture in the 1980s). But that’s essentially the only continu…
Article
Cell-Culture Advances Test Bioreactor Performance Models
Continuous considerations
In the past, continuous processing in perfusion mode was generally limited to cell-culture processes involving sensitive products that degrade under conventional batch …
Article
Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
Topics covered include:
1:47 - Where the industry is headed with real-time analysis
3:17 - Scaling up
4:57 - Cell perfusion
7:16 - Criti…
Article
Improving Upstream Predictability
Currently, he says, 50–60% of biopharmaceutical developers and manufacturers have either implemented or are considering use of perfusion for seed train or production bioreactor steps. Used with high c…
Article
Trends in Single-use Bioreactors
Galliher (Cytiva): The latest innovations include higher-power microbial bioreactors, as well as improved capabilities for continuous perfusion. Single-use stirred-tank fermentation technology has bee…