Search results for " growth" in Articles / App Notes
Article
Improvements in Protein A Chromatography
Bolton recently published a paper “Role of more than 40 years of improvement in Protein A chromatography in the growth of the therapeutic antibody industry,” and also presented at the spring ACS meeti…
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Being Thorough When Transferring Technology
Another challenge is a high amount of dissolved CO2 in culture, if not managed carefully, can lead to high osmolality and cessation of cell growth or productivity. Additionally, non-physiological diss…
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Critical Quality Attributes Challenge Biologics Development
The past decade has experienced a tremendous growth in the biologics portfolio of the biopharmaceutical industry. With the advancement of knowledge in analytical sciences, protein engineering, biology…
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Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
It minimizes the risk of microbial growth, increases product stability with extended shelf life, eliminates agitation and foaming during transportation, and increases flexibility during manufacturing …
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The Tide Stays High
Most publicly-traded services providers achieved revenue growth well in excess of 10% in 2016 (based on interim results), especially in those services that cater to clinical development (clinical supp…
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Biosimilars to Drive Modern Manufacturing Approaches
Bernstein financial analyst Ronny Gal predicted at the Biosimilars Council conference that biosimilars will experience strong market growth during the next few years, as regulatory issues related to p…
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Managing Biomanufacturing Capacity Expectations
“Retirement of very old plants is being exceeded by new capacity growth, [and] overall capacity needs are growing,” notes Greg Guyer, leader in biologics development and operations at Bristol-Myers Sq…
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Fed-batch supplements to boost cell culture performance
Cell growth and MAb production in the fed-batch cultures were compared with batch cultures. The results demonstrate increased viable cell yields and productivity in the fed-batch cultures.
Downloa…
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Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
Loadings on PC1 were heavily influenced by growth, osmolality, and amino acid concentrations. The feed system of the platform process was linked to the viable cell concentration. The correlation obser…
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Implications of Cell Culture Conditions on Protein Glycosylation
Optimum cell-culture development is achieved by working with bioreactors to enhance growth and productivity via selection of basal media and culture feeds and the timing for these feeds; optimizing bi…