Search results for " growth"
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Host-Cell Protein Measurement and Control
During the recombinant protein production, host cells also coproduce proteins related to the normal cell functions such as cell growth, proliferation, survival, gene transcription, protein synthesis, …
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Biomanufacturing Outsourcing Globalization Continues
Recent headlines are testament to growth in China. For example, Cytiva built two facilities in China for CMO JHL Biotech, including a KUBio modular biopharma factory in Wuhan that will house 2000-L si…
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Re-use of Protein A Resin: Fouling and Economics
Other significant attributes include the level of Protein A leachate in the pool, concentration of DNA in the pool, growth media composition, and the amount of lipids in the pool (Figure 4A).
Figu…
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Continuous Manufacturing: A Changing Processing Paradigm
Amgen, “Amgen Outlines Strategy, Growth Objectives And Capital Allocation Plans,” Press Release, Oct. 28, 2014.
12. Vertex, Form 10-K Annual Report, Filed Feb 11, 2014, http://investors.vrtx.com/s…
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Fermentation for the Future
It is also useful for the production of cytokines, growth factors, and plasmid DNA. Reinisch also notes that media costs for microbial fermentation are lower, although media costs for cell culture hav…
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New Era for Generic Drugs
Liability and labels
Meanwhile, the continued growth in generic drug market share has generated more legal challenges to product development and marketing. Recent Supreme Court decisions have raise…
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Pharma Investments Reflect Key Industry Trends
Shrinking facility size, growth of biologics, and emerging market demand influence pharma investments.
Aug 2, 2014
By: Cynthia Challener, PhD
Pharmaceutical Technology
Volume 37, Iss…
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Single-Domain Antibodies for Brain Targeting
…s selectively expressed on brain capillary endothelial cells such as transferrin or the insulin-like growth factor (IGF-1) by receptor-mediated endocytosis (32). An alternative strategy for enhancing…
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Single-Use and Continuous Processing Technologies Change Facility Design
With no waiting for cell growth and cell-culture bioreactors continuously operating, columns can be smaller than when they need to handle whole fermenter volumes at one time. Ultimately, the whole fac…
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Concentrating Feed—an Applicable Approach to Improve Antibody Production
Although higher concentrations of feed media could be obtained by raising pH, there was an optimal pH of feed media in which cell growth and antibody production were not adversely affected. The additi…