Search results for "Protein" in Articles / App Notes
Article
Novel Vaccine Technologies Meet the Need for Pandemic and Therapeutic Solutions
Examples include cell-culture, synthetic DNA, chimeric antigen, and recombinant protein nanoparticle vaccine technologies.
Egg-vaccine technology limitations
Traditional vaccine manufactu…
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Emerging Therapies Test Existing Bioanalytical Methods
Gene therapy, the transfer of genetic material into specific cells to modulate gene expression or produce a new/modified protein, was first tested in a clinical trial in 1990 (1). Researchers at the N…
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Leveraging Computational Models of Glycosylation for Biopharma QA
Glycosylation is also widely acknowledged as a major source of therapeutic protein heterogeneity (3), which is highlighted by work that found considerable glycosylation variation among different comme…
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Analysis of Glycosylation in Biosimilars
The structures of protein drugs such as monoclonal antibodies are made more complex by post-translational modifications. The most notable of these is glycosylation, where carbohydrate residues are att…
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Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
The typical platform process is generally comprised of an initial capture step with Protein A-chromatography, a first polishing step with cation-exchange media, and a final polishing step using anion-…
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Virus-like Particles as Therapeutic Moieties of the Future
VLPs displaying specific antigenic proteins can also be used as diagnostic agents (1).
Delivery vehicles
VLPs derived from human viruses are conditioned to disassemble in the intracellular mil…
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Moving PAT from Concept to Reality
In addition, a variety of on-line tools measure cell density (dielectric spectroscopy, fluorescence spectroscopy); protein aggregates (size-exclusion chromatography and ultra-high-performance liquid c…
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Unifying Continuous Biomanufacturing Operations
Reductions in protein product residence times are thought to help minimize the effects of adverse chemical or enzymatic modifications.
Researchers and process engineers are still grappling with ho…
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Single-Domain Antibodies for Brain Targeting
IgG, the main serum antibody, the intact form of which is almost exclusively used in therapeutic antibodies, is a Y-shaped, multidomain protein with antigen-binding sites located on the two Fab (antig…
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Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
…nent-free processes that have now become standard for producing recombinant antibodies, therapeutic proteins, and some vaccines. Although the same concerns for safety are ultimately expected to drive…