Search results for "Protein" in Articles / App Notes

Article Improving Process-Scale Chromatography
The development of new resin chemistries including enhancements to Protein A for monoclonal antibody (mAb) capture, increasing use of automation, implementation of single-use technologies, and explora…

Article Process Chromatography: Continuous Optimization
Host-cell proteins, host-cell DNA, other process-related contaminants, and product-related impurities (e.g., aggregates, incorrectly modified or unfolded proteins, etc.) must be removed. A combination…

Article Antibody Production in Microbial Hosts
With more than 200 recombinant proteins on the market today, the biopharmaceutical industry is expected to reach approximately $180 billion by 2016 (1). Therapeutic mAbs and their derivatives—such as …

Article Cell-free Expression Systems Pose Cell Culture Alternative
…allenges, a major one being waste disposal, confirms Tim Ding, senior scientist in the Antibody and Protein Production Division at Creative Biolabs, a US-based custom service provider of antibody pro…

Article Advances in Engineering of Protein-Based APIs
Today, monoclonal antibodies (mAbs) have become one of the predominant forms of protein-based biopharmaceuticals, with humanization and fully human monoclonals contributing to their increasing success…

Article Concentrating Feed—an Applicable Approach to Improve Antibody Production
Recombinant protein production in the biopharmaceutical industry mostly relies on fed-batch mammalian cell culture (1, 2). Often in fed-batch processes, the feed volume can be more than 1000 L for a 5…

Article Innovative Chromatography Resins Can Improve Purity and Quality
A generic capture step for mAbs and Fc fusion proteins has been robustly established by classical Protein A affinity resins, says Oliver Schub, director of Business Development at Navigo Proteins, a s…

Article Continuous Manufacturing: A Changing Processing Paradigm
Langer notes that perfusion “can enable manufacture of inherently less-stable and labile proteins” and is less stressful in general to proteins, resulting in more consistent, better-quality products t…

Article Reimagining Affordable Biosimilars
With an anticipated valuation of over $200 billion by 2022, this popularity of protein-based biologics can be attributed to their unique target specificity in proteinprotein interactions for the trea…

Article Process Chromatography Selection for Downstream Processing Applications
… (Cytiva): If one excludes mAbs, then the molecules of interest are generally peptides, recombinant proteins, or vaccines. For these molecules, chromatographic techniques such as ion-exchange, hydrop…

Show All Results

Previous PageNext Page