Search results for " bioreactor"

Article Implementation of Raw Material Control Strategies in the Manufacture of Single-Use Bioprocessing Containers
Disposable bioprocessing containers, such as those used for fluid storage or as bioreactor bags, are usually made from multilayer films. Typical resins used in multilayer films include, but are not li…

Article Improving PAT for Biologics
“We are excited about the use of Raman and NIR probes for biopharmaceutical manufacturing because these probes have the ability to provide real-time information about the process and product in the bi…

Article Stirring up the fermentation game
… technology by biomanufacturers using microbial systems has been inhibited by the lack of single-use bioreactor systems capable of accommodating the unique requirements of microbial cultures. Bioreac…

Article Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The cells in the 10 L cultures were grown on Cytodex 1 microcarriers (3 g/L) in the WAVE Bioreactor 20/50 system. The cells were grown to a cell concentration of approximately 3 × 106 cells/mL. The ce…

Article A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
Click here to learn more >> We have developed a reliable small-scale model for a monoclonal antibody (mAb) perfusion process using TPP® TubeSpin® Bioreactor tubes and the ReadyToProcess WAVE 25 R…

Article Remote Monitoring and Big Data Advance Upstream Automation
…as important for drastically reducing and even in some instances completely eliminating manual daily bioreactor sampling. “These systems integrate with metabolite analyzers and cell counters and can …

Article The Importance of Process Intensification and PAT for Achieving Real-Time Release
As the industry has matured, effective manufacturing platforms and analytical tools and technologies appropriate for fed-batch manufacturing in stainless-steel or single-use bioreactors have also adva…

Article Moving PAT from Concept to Reality
In bioreactors, in-line sensors measure pH, temperature, dissolved oxygen (DO), and carbon dioxide; in-line optical sensors (Raman, NIR) are coupled with multivariate modeling to measure metabolites. …

Article Process Development: What May Lie Ahead in 2018?
Single-use bioreactors, for instance, are increasingly available from a host of vendors, and suppliers of such technology have made “significant advances in film technologies, bioreactor designs, stir…

Article Platform Technologies Improve Protein Expression
He points to the use of high-cell-density, fixed-bed bioreactors for adherent cell culture as an exciting new development. “With these bioreactors, it is possible to increase cell densities from 10-20…

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