Search results for " bioreactor"
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Perfusion Culture Using TFF or ATF as Cell Retention Method
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Perfusion processes have many advantages such as being favorable for product quality and supporting efficient facility utilization by offering the possibility…
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Scalable Viral Vector Manufacturing
For example, single-use bioreactors, filtration, and chromatography techniques are suitable for virus production.
Due to the diversity of viruses, platform solutions are challenging to implement e…
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Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
The selected fed-batch culture conditions supported mAb titers of approximately 4 g/L in bioreactor cultures.
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State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
The continued relative lack of single-use microbial bioreactors and suppliers/vendors continuing to promote standardized (versus new) approaches (i.e., use of CHO and similar host cell lines) are fact…
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The Challenge of Disruptive Technologies in Bioprocessing
“One issue that could occur is the load of a high titer product stream from a large-volume bioreactor onto a column with given, limited size and thus limited capacity (similar with filters), and all o…
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Biopharma Seeks Balance
… nucleation for lyophilization processes, predictive modeling for process monitoring and closed loop bioreactor control, next-generation sequencing, continuous manufacturing for downstream processes,…
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Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
WuXi Biologics, “WuXi Biologics to Invest €325 Million to Build Largest Biomanufacturing Facility Using Single-Use Bioreactors in Ireland,” Press Release [4], April 30, 2018.
5. R.A. Rader, E.S.…
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Putting Viral Clearance Capabilities to the Test
On the other hand, the laboratory model viruses have a great chance of contaminating bioreactors using continuous cell lines.”
Gilljam identified other challenges. “Due to the volume tested in the…
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Achieving Efficient Adenovirus Upstream Production
This application note describes the production of adenovirus in HEK293 suspension cells in a bioreactor system. Triplicate cultures demonstrate a reproducible and robust batch production of adenovirus…
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Leveraging Data for Better Biopharmaceutical Process Control
As she says, “PAT is not just sticking a probe into a bioreactor. A great deal of work is needed to make advanced process monitoring and control approaches feasible.” At this point, due to higher comp…