Search results for " bioreactor"
Article
Strategizing for Rapid Changeovers in Biologics Manufacturing
…CIADM) by the US Department of Health and Human Services, uses flexible manufacturing and single-use bioreactors to respond to the COVID-19 pandemic. “Flexible design will help enable us to complete …
Article
Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
A typical monoclonal antibody (mAb) process may require 2000 L of a buffer and more than 100,000 L per batch based on titer and bioreactor volume (1, 2). As a result, the variety of buffer solutions u…
Article
Next Generation Process Chromatography
Just like single-use bioreactors I believe that the advantages of Fibro are not immediately clear in large scale >500-kg processes but I believe that once end users have experience using this platform…
Article
Gene Therapies Push Viral Vector Production
Gene Therapies Push Viral Vector Production
Viral vectors show promise as a delivery mechanism for gene therapy, but which virus types are commercially viable?
By Feliza Miraso…
Article
Implementation of Process Intensification Strategies Across the Entire Cell Culture Workflow
…the industry in relation to process intensification and give specific examples of how both N-1 and N bioreactor operations can be intensified using the latest technologies. Furthermore, the importanc…
Article
Scalable ADCF Virus Production Using HyClone™ VaccineXpress Medium
The results were used for scaling up the process to a ReadyToProcess WAVE 25 bioreactor system at a 2-L working volume. The data show that the ADCF process using VaccineXpress for rotavirus propagatio…
Article
Next Generation Bioprocesses: Mapping Roads to the Future
In upstream processing, this can be exemplified by intensified seed train or intensified production bioreactor operations. In downstream processing, it can be intensified capture, in-line virus inacti…
Article
Scale-Up Model of a mAb Process from Microbioreactor to XDR-1000
All investigated bioreactor systems displayed similar trends over time and acceptable variability between cultures for viable cell density and viability profile, product titer, lactate, and product qu…
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
… the unit operation cost was 19% to 33% less for a membrane process used on 1000-L and 5000-L scales bioreactor volumes and various mAb titres. In addition, buffer volume was decreased by up to 55%. …
Article
The Outlook for CMO Outsourcing in 2019
The industry is starting to see a major trend for CMOs adding 1000–2000-L single-use bioreactor process lines for commercial manufacturing as products currently in development manufactured with single…