Search results for " filtration"
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Next Generation Bioprocesses: Mapping Roads to the Future
In downstream processing, it can be intensified capture, in-line virus inactivation, flow through polishing, in-line virus filtration, or single-pass filtration.
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A Plastic Pipeline for Commercial Bioprocessing?
More than 75% use filled media bags, preassembled tubing sets, depth filters, bioreactors, sampling systems, and tangential flow filtration devices. Less than two-thirds use disposable chromatography …
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Integrated Semi-Continuous Process for mAb Production
In brief, the mAb process consists of perfusion cell culture, continuous capture chromatography, viral inactivation (VI), post VI filtration, batch polishing chromatography, and a final pH adjustment …
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The Challenge of Disruptive Technologies in Bioprocessing
A salt-tolerant resin can be beneficial to a purification process by decreasing the need for dilution or eliminating tangential flow filtration steps all together. In addition, there has been increase…
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Bioburden Control in the Biopharmaceutical Industry
Field, “Bioburden Control at the Sterile Filtration Step: A Risk-Based Approach,” presentation to European Biopharmaceutical Enterprises (May 2013).
10. Critical Process Filtration Inc., “Partic…
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The New World of Biopharmaceutical Manufacturing
Single-use sensors have been developed for a variety of process parameters for downstream steps such as chromatography, tangential flow filtration, direct filtration, and fill/finish, as well as for s…
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Unifying Continuous Biomanufacturing Operations
In terms of cell retention devices, alternating tangential filtration (ATF) allowed a significant technological step ahead compared with tangential-flow filtration (TFF), comments Morbidelli, although…
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Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Disposable, single-use filtration is an alternative to outdated centrifugation methods that are difficult to scale and complicated to use. Expanded-bed absorption (EBA) offers an alternative to oversi…
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Ensuring the Biological Integrity of Raw Materials
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Standard procedures for inactivation of adventitious agents include the use of heat, filtration, pH, and gamma irradiation. Thorough cleaning of equipment, testing, and review of material sour…
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Selection Guide Size Exclusion Chromatography Columns and Media
Size exclusion chromatography (SEC), also called Gel filtration (GF), separates molecules on the basis of differences in size as they pass through a SEC medium packed in a column. A variety of media…