Search results for " bispecific" in Articles / App Notes
Article
Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
One of these promising groups of antibodies is called bispecifics, where one antibody can simultaneously bind to two targets.
Advanced antibody engineering has resulted in the ability to manufactu…
Article
FDA Provides Guidance on Bispecific Antibody Development Programs
FDA published final guidance on May 24, 2021 to provide industry and stakeholders with recommendations for the development of bispecific antibodies including recommendations for regulatory, quality, n…
Article
Optimization of a two-step purification method for bispecific antibodies
New and improved antibody bioprocesses and recombination techniques have contributed to a surge in the numbers of bispecific antibody constructs currently in clinical trials.
Alligator Bioscience A…
Article
Bispecific Antibody Purification: Insights and Case Studies
Here are some industry insights to help you navigate the bispecific jungle.
Read Article
Article
Single-Step, Protein A Chromatography Process for Bispecific Antibodies in Early Screening
Learn more about bispecific purification
Article
Capture of Bispecific Antibodies and Removal of Product-Related Impurities
Many of these variants, especially asymmetric bispecific antibodies, are prone to aggregation or to forming product-related impurities such as homodimers and half antibodies during cell culture. The s…
Article
Optimization of a Two-Step Purification Method for Bispecific Antibodies
Alligator and Cytiva developed an efficient downstream purification process for a cancer immunotherapy bispecific antibody (bsAb).
Read more
Article
Optimizing KiH bispecific antibody chromatography steps
Bispecific antibodies (bsAbs) are a promising class of therapeutic agents due to their ability to bind to two different types of antigens or two different epitopes on the same antigen. This a…
Article
Purification strategies for antibody-derived entities: bispecifics and fragments
Here we present strategies for purifying bispecific antibodies and antibody fragments having the molecule type and the impurity profile in mind.
Watch video
Article
Selecting Chromatography Resins for Bispecific Antibody Purification
Targeting enhancement with two active antibody arms makes bispecific antibodies (bsAbs) highly attractive for the treatment of cancer and other diseases. Their purification can be more challen…