Search results for "Upstream" in Articles / App Notes
Article
Is Your Single-Use Facility Designed with the End in Mind?
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Up-front design considerations can improve your long-term processing flexibility and ability to expand.
Article
Developing a Continuous Large-Scale Perfusion Cell Culture Process
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Perfusion processes enable continuous operation over extended periods of time by constantly providing fresh nutrients for the cells and simultaneously removing spent…
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A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAb at Large Scale
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As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quick…
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Scaling a mAb Production Process to Xcellerex Bioreactors
This article discusses moving a monoclonal antibody (mAb) production process from a microscale bioreactor to the Xcellerex XDR single-use platform.
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Production of Recombinant Adeno-associated Virus Vectors Using Microcarrier Culture of HEK293T Cells
As of March 2020, more than 4310 gene therapy clinical trials have been performed worldwide, with only 518 of them in Phase III and Phase IV. As the gene therapy projects enter clinical Phase III or g…
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Flavivirus Vaccine: Accelerate Development and Production with Modern Tools and Solutions
This article gives an overview of modern tools and solutions, adding flexibility and speed to both upstream and downstream operations in flavivirus vaccine production.
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Gene Therapies Push Viral Vector Production
Learning how process parameters in the upstream process influence the purification process is fundamental for a good quality-by-design strategy. Furthermore, it will be interesting to see the developm…
Article
Fortem: One Film for Single-Use Bioprocessing
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Single-use technology has been transforming the modern biomanufacturing workflow. Single-use bags can now be found at every stage of bioprocessing: bioreactor and mi…
Article
Mapping a Route for Cell and Gene Therapy Process Development
…cells) within the bioreactor is necessary to gather the data needed to enable effective scale up of upstream processes, Lamproye adds. In many cases, he notes that the need to develop, validate, and …
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Factors Which Impact mAb Process Scale-Up
Thinking about your mAb scale-up processes early on can help avoid common pitfalls. Fast Trak™ scientists discuss factors that can influence a successful scale-up outcome.