Search results for "Upstream" in Articles / App Notes
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QbD Improves Cell-Culture Process Control
QbD Improves Cell-Culture Process Control
A quality-by-design approach that implements PAT offers advantages in upstream cell-culture processing.
By Feliza Mirasol
Mar…
Article
Single-use Bioreactors Have Reached the Big Time
…d meeting the growing expectations from our customers,” asserts Morgan Norris, general manager of upstream and cell culture with Cytiva.
Whereas the first disposable bioreactors were ‘plastic’ co…
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Mixing dynamics in a large volume single use mixer
Upstream applications such as medium preparation and harvest require fast and efficient mixing whereas downstream mixing operations used in purification and separation processes require sensitive mi…
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Trends in Single-use Bioreactors
In fact, we have sold a number of hybrid facilities with a combination of both single-use upstream and stainless steel systems. On the other hand, introducing a single-use bioreactor into a traditiona…
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A Q&A With Parrish Galliher About Adopting Single-Use Systems
This week, Process Development Forum speaks with Parrish Galliher, Chief Technology Officer Upstream at Cytiva, about trends within the bioprocess area.
What’s one of the biggest t…
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Q&As with Industry Leaders
…k Whitelock, Commercial Modeling Specialist, Cytiva
Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
Chris Spivey, BioPharm International
…
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Q&A with Industry Leader Konstantin Konstantinov, Genzyme Vice-President
Up until a few years ago, continuous processing was limited to upstream only, because there were no unit operations available for downstream. But now several companies, including Cytiva, are making un…
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Raw Material Variability
Many of these issues would be upstream in the cell-culture or fermentation step but could also be downstream in purification. The ‘blackbox’ nature of upstream processes makes things doubly difficult.…
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Bioprocessing Advances in Vaccine Manufacture
These improvements are much needed, as advances in upstream manufacturing (everything through product formation in the bioreactor) causing capacity constraints and problems, because later downstream p…
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Instructional Videos for Bioprocess Equipment
Upskill your use of Cytiva equipment
To get the most performance out of your bioprocess equipment, sometimes you need a refresher training. Cytiva offers free on-demand instructional vide…