Search results for "Upstream" in Articles / App Notes
Article
Extractables in Single-Use Systems Used in ADC Manufacturing, Part 2
We performed extractables studies on single-use chromatography and tangential flow filtration systems using common solvents in ADC manufacturing, DMA and DMSO. The low levels of extractables f…
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Exosome isolation by tangential flow filtration and size exclusion chromatography
We demonstrate a scalable workflow for the isolation of exosomes—a type of extracellular vesicle with significant potential for targeted drug/gene delivery. For research and development and di…
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Right the First Time: Bioreactor Scale and Design Translation
Cell culture process transfer requires a good understanding of the physicochemical conditions within a bioreactor. This includes the hydrodynamic environment induced by the agitator and the …
Article
Selecting Chromatography Resins for Bispecific Antibody Purification
Targeting enhancement with two active antibody arms makes bispecific antibodies (bsAbs) highly attractive for the treatment of cancer and other diseases. Their purification can be more challen…
Article
Dear lentivirus: We have not forgotten about you and how to improve your polishing recovery
Lentiviruses are commonly used for both chimeric antigen receptor (CAR) T cell therapy and ex vivo gene therapy.
Vector purification is very challenging due to low stability of these envel…
Article
How to put mechanistic modeling into practice
Make it happen! Learn about insider recommendations to get started with in silico process development.
Check out our resources on good modeling practice, case studies, and other publication…
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Process Development for Viral Vectors
Scaling viral vector processes can be challenging, but it doesn't have to slow you down. Cytiva can help you own your process and gain valuable expertise. Download a case study from Fast Trak™…
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Balancing AAVs Versus LLVs
Knowledge of adeno-associated variant's infection pathway is based on only a few serotypes. The prevailing understanding is that serotypes bind to different, or have differential affiniti…
Article
Register to HTPD pre-conference day on mechanistic modeling
On Monday, October 30, 2023 in Malta, you will have the chance the join the Cytiva pre-conference sessions on mechanistic modeling, which will be followed by the 6th HTPD meeting.
Re…
Article
Better bioprocess scaleup with Bioreactor Scaler Pro
Are you still using the manual input, trial-and-error method when scaling your cell culture process, spending long hours in the lab analyzing uncertain data?
With Bioreactor Scaler Pr…