Search results for "host" in Articles / App Notes
Article
Emerging Therapies Test Existing Bioanalytical Methods
Most of the vectors utilized are likely to have modifications that will trigger the host to recognize it as “foreign” and elicit an immune response that may change the clearance of the vector prior to…
Article
Faster Flavivirus Vaccine Production
Surface Plasmon Resonance (SPR) analysis during process development provides data about virus behavior and host interactions. This is valuable both for regulatory compliance and future drug developmen…
Article
Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
They then prioritized attributes based on their importance, and found the following to be key:
• Glucose
• Aggregates
• Host cell protein (HCP)
• Cell viability
• Viable cell densi…
Article
Webinar On Demand: Expanding SPR Uses in Antibody Effector Function Determination
CQAs typically include data on how the candidate interacts with target proteins, as well as process-related CQAs such as protein size, homogeneity, presence of host cell proteins (HCP) etc.
In th…
Article
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
First, recombinant production of all enzymes was achieved in Escherichia coli or yeast hosts. This required discovery of some genes encoding plant enzymes that had never been produced recombinantly (e…
Article
Optimizing Late-Stage and Commercial Cell-Culture Processes
… valuable modeling input; it can shorten the development period for complex molecules or unfamiliar host cell lines (e.g., in-licensed molecules),” says Laird.
“In a commercial-manufacturing s…
Article
Process Development: What May Lie Ahead in 2018?
Single-use bioreactors, for instance, are increasingly available from a host of vendors, and suppliers of such technology have made “significant advances in film technologies, bioreactor designs, stir…
Article
Improvements in Protein A Chromatography
You mention that you sometimes are asked “Why do you still use Protein A?” Why do you?
Protein A chromatography provides high yield while providing up to 3 logs of host cell protein removal and 4…
Article
Biopharma in 2016: Higher Quality Drugs, Less Expensive Manufacturing
…Continuous Processing for the Production of Biopharmaceuticals
Antibody Production in Microbial Hosts
Single-use Technologies in Downstream Process Intensification
A Risk-Based Genetic Ch…
Article
Drug Quality Key to Innovation and Access
By Jill Wechsler
Amidst multiple challenges to the structure and governance of the US healthcare system, bio/pharmaceutical manufacturers will face a host of issues in bringing safe and effective …