Search results for "host" in Articles / App Notes
Article
Strategizing for Rapid Changeovers in Biologics Manufacturing
Any live biological agents, whether they be the host organisms or adventitious agents, must be effectively removed/inactivated from HVAC, facility, and equipment surfaces (both exterior and product pa…
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Lentiviral Vector Upstream Process in Single-use Bioreactors
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Lentiviruses exhibit many desirable properties as gene transfer vehicles, such as high transduction efficiencies, ability to infect both dividing and nondivi…
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Can Vaccine Development Be Safely Accelerated?
They possess a surface spike (S) glycoprotein that binds to host cell receptors, and the nature of this protein is believed to determine the main properties of each coronavirus. SARS-CoV was the first…
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Improving Upstream Predictability
Over the past three years, Mohindra adds, Lonza has significantly improved host cell expression levels along with its understanding of the design space and interactions between cells, media components…
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Flexible Facilities for Viral Vector Manufacturing
The BioPhorum Group hosted an industry collaboration that proposed a standardized, modular design approach to help advance facility design in the industry (2). While the initial project looked at a mo…
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2019’s Top Bioprocessing Trends and What to Expect in 2020
…ng processes, the industry has been somewhat slow to adopt PAT-focused platforms and services for a host of reasons that include regulatory and cost issues. However, technological advancements made d…
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The Evolving Role of Starting Materials in Cell and Gene Therapy
For years, the mesenchymal stem cell (MSC) therapy field struggled with intermittent loss-of-function issues, despite promising clinical trial results for treating a host of different diseases. Severa…
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A Successful First Year for Testa Center
The bioprocess pilot-scale facility in Uppsala, Sweden, has hosted 15 national and international projects and more than 2000 study visits since its opening in 2018.
Testa Center, a not-for-prof…
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Case Study: Oncolytic Adenovirus Production
Selectively engineered, the virus not only destructs the target tumor cell, but also stimulates the host’s anti-tumor immune response.
This case study describes a robust upstream process and downs…
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Moving PAT from Concept to Reality
Numerous at-line analyses evaluate host cell proteins (HCPs), DNA, viable cell density, bioburden, aggregates, product concentration, and particulates.
One of the greatest difficulties with many c…