Search results for " biotherapeutics" in Articles / App Notes

Article Modeling the Degradation of mAb Therapeutics
Modeling the Degradation of mAb Therapeutics Kinetic models can be used to study aggregation and fragmentation to help ensure stability. By Anurag S. Rathore, Rohit Bansal …

Article Techniques for Improving Process Development for Exosome-Derived Therapeutics
One promising biotherapeutics category that may hold the key for achieving this goal is exosomes. These nano-scale membrane sacs are mediators of intercellular communication and can be exploited as ca…

Article Platform Technologies Improve Protein Expression
“The goal beyond making some of these new entities viable is achieving a significant reduction in COGM, thus increasing the affordability of biotherapeutics and improving overall healthcare economics,…

Article Impact of Media Components on CQAs of Monoclonal Antibodies
Major mammalian expression systems for the production of biotherapeutics include NS0 cells, baby hamster kidney (BHK) cells, hybridoma cells, PER.C6 cells, human embryonic kidney (HEK) cells, and Chin…

Article Biacore Concentration and Ligand-Binding Analyses
Biotherapeutic drugs including antibodies, cytokines, and hormones are used for treatment of a variety of diseases including arthritis, cancer, and diabetes. Compared to traditional small-molecule dru…

Article Biomanufacturing Outsourcing Globalization Continues
May 02, 2015 By Eric S. Langer BioPharm International Volume 28, Issue 5 Biopharmaceutical manufacturing clusters continue to emerge outside of the traditional hubs of North America …

Article Ligand-Binding Assays and the Determination of Biosimilarity
The importance of binding activity Most biotherapeutics rely on specific binding activities to achieve a clinical effect. Therefore, matching the binding activities of a biosimilar candidate to th…

Article Automated Concentration and Diafiltration of Multiple siRNA Samples
A team of scientists collaborated on a project to transfer a conventional manual concentration/diafiltration process for siRNA production.  ABSTRACT The use of small-interf…

Article Address the complexity of protein characterization
Since the FDA approved the first monoclonal based therapy in 1985, mAbs have had significant clinical success and have been used to provide effective treatment for a range of diseases. Durin…

Article Introducing the VH3 ligand ELISA kit
Ensuring the safety and efficacy of antibody-based therapeutics is crucial in biotherapeutic manufacturing. Accurate testing for ligand leakage from affinity resins is a key part of this proce…

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