Search results for "purification" in Articles / App Notes
Article
Ensuring the Biological Integrity of Raw Materials
“If there is a contamination, you catch it early—before you send the batch for purification.”
Trending strategies for testing raw materials are included in GMP practices, quality by design, and pr…
Article
Increase Efficiency in Experimentation with Design of Experiments
Setting up an efficient study can help you save time and allow you to get the most out of screening and optimization experiments during method development. Also, good planning and relevant experimen…
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Biopharma in 2016: Higher Quality Drugs, Less Expensive Manufacturing
…e Development
Overcoming Buffer Challenges With In-Line Conditioning
A Platform Approach to Purification of Antibody Fragments
References
1. Walker, Nigel, Innovation at the Heart of …
Article
Advancing Single-Use Technology Through Collaboration
…at uses fully single-use technology is the bioreactor, which is far upstream: there are significant purification processes in place further downstream. According to Duncan Low, scientific executive d…
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Mixing dynamics in a large volume single use mixer
Upstream applications such as medium preparation and harvest require fast and efficient mixing whereas downstream mixing operations used in purification and separation processes require sensitive mi…
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Technology solutions simplifying chromatography unit operations
This application note describes how modern tools and technology solutions can help facilitate chromatography operations for an effective and productive protein purification process.
Download the a…
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Affinity Chromatography Handbook in 3 Volumes
Purification can be in the order of several thousand-fold and recoveries of active material are generally very high.
Learn more about AC in these updated Handbooks.
The Affinity Chromatography…
Article
Analysis of Glycosylation in Biosimilars
Monosaccharide analysis can also give a purity check: high levels of glucose might suggest the breakdown of Sephadex beads, for example, in the purification process, and high mannose levels may indica…
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Vocabulary of the chromatographer
Similar to other technical areas, chromatographers generate their own vocabulary, all with a good scientific purpose and for a common understanding. However, the same terminology can be used in othe…
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Maximize resin usage with continuous bioprocessing
The technology employs three or more chromatography columns to create a continuous purification step. In a PCC setup, columns are switched between the loading and nonloading steps, such as wash and el…