Search results for " fluid"
Article
Cell-Culture Advances Test Bioreactor Performance Models
In particular, the inexpensive computing power and excellent computational talent entering the biopharma industry, combined with improvements in computational fluid dynamics (CFD) and metabolic modeli…
Article
Moving PAT from Concept to Reality
On-line sensors are connected to process side streams and perform periodic automatic sampling, returning fluid back to the process streams after analysis is complete. At-line—or off-line—analyses invo…
Article
Emerging Therapies Test Existing Bioanalytical Methods
qPCR is used to quantify a viral genome in serum, tissue, or body fluids for the purpose of pharmacokinetics (PK), biodistribution, or vector shedding evaluations (3,4,6). It is also used to measure t…
Article
Achieving Process Balance with Perfusion Bioreactors
Advances in single-use technologies, sensors, and cell retention systems facilitate processes designed for the long run.
By Cynthia A. Challener
MG/Stock.Adobe.com
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Article
Ensuring Viral Safety of Viral Vaccines and Vectors
Limitation of this method is the flow rate of the fluid, which needs to be modulated for optimal results (21).
Gamma irradiation—ionizing radiation from a radioactive Cobalt 60 source—breaks bo…
Article
Development of Purification for Challenging Fc-Fusion Proteins
In most two-column downstream processing platforms, the first column is Protein A (ProA), which binds the target mAb directly from the harvested cell culture fluid. A low pH buffer is routinely used t…
Article
Impact of Media Components on CQAs of Monoclonal Antibodies
While natural media consists solely of naturally occurring biological fluids and has been proven to be quite useful and convenient for a wide range of animal cell cultures, a key disadvantage is the p…
Article
Process Chromatography: Continuous Optimization
Even so, there are many impurities present in the harvest cell-culture fluid obtained after removal of the cells or yeast and media. Host-cell proteins, host-cell DNA, other process-related contaminan…
Article
Hybrid Bioprocessing: A Q&A with Andrew Sinclair
In my view, it's where within the manufacturing process, there are a combination of single-use (SU) materials and re-usable materials in contact with the process and associated fluids. This often refe…
Poster
Resin selection to optimize the flexural strength of bioprocess film
Single-use bioprocess technology offers several advantages for manufacturing biopharmaceuticals, such as increased transportability of fluids throughout the bioprocess workflow and a greater diversi…